In the Department of Zahnärztliche Werkstoffkunde und Biomaterialforschung (ZWBF), we are looking for a

PROJECT DESCRIPTION

In vitro models are becoming increasingly important for gaining a mechanistic understanding of tumor biology and for testing new drugs for tumor therapy. However, established 2D in vitro models cannot adequately represent all pathophysiological properties. This limitation requires their further development into more complex 3D in vitro models consisting of several cell types that better simulate the in vivo situation.
The aim of this project is to develop a 3D in vitro model capable of representing the entire hematogenous metastatic process of a breast cancer tumor in the liver. In the current project phase, the synthesis of a liver-like tissue will be optimized. The liver model consists of relevant liver cells, which are embedded in a hydrogel mixture adapted to the native extracellular matrix (ECM). Important evaluation parameters for the suitability of the hydrogel as an ECM substitute are cell viability and morphology, as well as hydrogel stiffness and porosity.

REQUIREMENTS

• You are highly motivated
• You have a responsible and accurate way of working
• First experience in a biological lab is of advantage
• Background: Biology, biotechnology, biomedical engineering, material sciences or related fields