Summer Intern/DMPK PBPK Modeling at GSK

Upper Providence, Pennsylvania, United States -

Full Time

Start Date

Immediate

Expiry Date

14 Aug, 26

Salary

43.0

Posted On

16 May, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

PBPK Modeling, Simcyp, ADME Characterization, Pharmacokinetics, Pharmacodynamics, Scientific Writing, Verbal Communication, Data Analysis, QSAR Prediction, Drug Discovery

Industry

Pharmaceutical Manufacturing

Description

Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Department Description Drug Metabolism & Pharmacokinetics (DMPK) Group is responsible for integrating the absorption, distribution, metabolism, and elimination (ADME) characteristics of drug candidate molecules from in vitro, pre-clinical and clinical information. More specifically DMPK Modelling group provides in vitro to in vivo translation, human dose predictions, and clinical using compartmental pharmacokinetics (PK) and physiologically based pharmacokinetics (PBPK) and pharmacodynamics (PD). This co-op position will focus on Antibody-Drug Conjugates (ADCs), specifically on the mechanistic PBPK modeling for their payloads. Watch this before you apply! GSK Early Careers Top Tips: Learn practical advice from GSK on how to prepare a standout application and succeed in your early careers journey: GSK Early Careers Top Tips Job Description This position offers a unique opportunity to develop advanced ADC PBPK modeling skills within the DMPK Modeling group. The PBPK science Co-op will contribute to establishing a generic, reusable payload PBPK framework in Simcyp, applicable across diverse ADC modalities. This work will encompass: Comprehensive characterization of ADC payload ADME using both internal and published data. Independent development and validation of PBPK model for ADC payloads in Simcyp, often utilizing Trastuzumab-based ADCs as an exemplar system to explore mAb PK, linker stability, and payload exposure. Integration of mechanistic data or QSAR-predicted parameters to ensure broad applicability of models, identifying key data gaps and informing future ADC design strategies. Collaboration across various cross-functional teams (toxicology, biology, chemistry, clinical pharmacology, formulations) to apply model-informed drug development strategies for ADCs. Work towards building a template PBPK model in Simcyp for multiple ADC payload chemotypes, integrating mechanistic sub-models or QSAR-based predictions. Present modeling outputs in internal team and department meetings. The goal is to be able to generate a high-impact publication detailing the generic ADC payload PBPK model and its applications. Minimum Qualifications Pursuing a Master's or PhD in a relevant scientific discipline (Pharmacokinetics, Pharmacology, Biochemistry or other DMPK related sciences). Must be able to work full-time (35-40 hours/week) throughout the duration of the 3 to 6-month internsip (May/June ~ August to December 2026). Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible. Preferred Qualifications Experience with application of PBPK software SimCYP. Basic knowledge of DMPK processes in drug discovery and development. Basic understanding of the in vitro/in vivo experiments used to describe general ADME principles especially drug absorption and drug distribution. Scientific writing and presentation ability with excellent verbal communication skills. Eligibility Requirements Must successfully pass a drug screen and background check prior to assignment target start date. Once your application is submitted, you will be prompted to complete our immersive GSK Digital Assessment. A passing score is required to proceed in the application process. After completing the assessment, a recruiter will review your application and contact you with next steps. Please note: We recommend using your personal email when submitting your application as school emails tend to block external senders. If you do not receive an automated email after submitting your application, be sure to check your spam folder. Benefits While GSK embraces a flexible work environment, we do require certain positions to be onsite. Candidates who are hired for an on-site role or hybrid role, and reside outside of 50-miles from their assigned work location, are eligible for relocation stipend. This is a one-time payment to help offset housing & relocation expenses. Please refer to the position details for the requirements of each position. GSK Interns and Co-ops are offered a competitive hourly pay rate and benefits. Please note, benefits eligibility determined the month following date of hire. This job posting is for a temporary role as an employee of Atrium on assignment at GSK. The individual selected for this role will be offered the role as an employee of Atrium; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by Atrium upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on several factors, including skills, competencies, experience, educational degree obtained, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirement. Pay Rate Range: $22/hr to $43/hr Interested in learning more? Register now on our digital learning platform (GSK Get Ahead - Connectr) where you can access interview and assessment hints and tips, speak to a mentor and learn more about life at GSK.

Responsibilities

Develop and validate mechanistic PBPK models for Antibody-Drug Conjugate (ADC) payloads using Simcyp. Collaborate with cross-functional teams to apply model-informed drug development strategies and contribute to a high-impact publication.