UNIV - Postdoctoral Fellow - Department of Biochemistry at MUSC Health Florence Medical Center

Charleston, South Carolina, United States -

Full Time

Start Date

Immediate

Expiry Date

27 Jun, 26

Salary

0.0

Posted On

29 Mar, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Multi-omics Data Analysis, Bioinformatics, Statistical Analysis, RNA-seq, Lipidomics, Phospho-proteomics, Hypoxia Research, Tumor Metastasis, Drug Resistance, Career Development Planning, Mentoring, Organizational Skills, Communication Skills, Interpersonal Skills

Industry

Hospitals and Health Care

Description

Job Description Summary The department of Biochemistry & Molecular Biology at MUSC has an immediate opening for a highly motivated and collegial Postdoctoral Fellow in the laboratory of Dr. Noel Warfel. The Warfel lab focuses on the role of hypoxia and reoxygenation in tumor metastasis and drug resistance. The Successful candidate will perform integrated multi-omics, statistical and bioinformatics analysis to understand how temporal hypoxia alters cancer cell resistance to therapy and related biological processes. The lab is also invested in drug development and testing in prostate cancer and other solid tumors. The candidates will work to integrate multiomics data sets, including RNA-seq, lipidomics, and phosoho-proteomics Entity Medical University of South Carolina (MUSC - Univ) Worker Type Employee Worker Sub-Type Regular Cost Center CC001336 HCC Recruitment & Retention Pay Rate Type Salary Pay Grade University-00 Pay Range 0.00 - 0.00 - 0.000 Scheduled Weekly Hours 40 Work Shift Job Description Job Purpose: The position will entail a combination of unbiased discovery and hypothesis-driven research to derive causal relationships between hypoxia-driven pathways contributing to cancer drug resistance. The candidate will be responsible for the generation and analysis of large-scale datasets and relating those findings to generate testable models for mechanistic investigations. Key responsibilities will be to integrate multi-omics to uncover mechanisms of therapeutic resistance and identify biological vulnerabilities related to changing oxygen in tumors. The candidate will work with the PI to implement a career development plan and participate in various career advancement opportunities. The candidate will also mentor undergraduate/graduate students and postdoctoral fellows in the Lab. Additional Knowledge, Skills, & Abilities Preferred: Prior experience with multi-omics data analysis and publications in bioinformatics are preferred. Must have the ability to think creatively and work independently as well as part of the team. Must have strong organizational skills, verbal and written communication skills, and interpersonal skills. Job Duties: 30% - Analyze and interpret complex transcriptomic, proteomic, and lipidomic datasets molecular datasets to identify novel biology related to tumor progression and metastasis 30% - Collaborate with graduate students and scientists at MUSC to identify actionable targets for mechanistic evaluation of tumor biology 15% - Work with the PI to create a career development plan and participate in various career advancement opportunities. 15% - Interact and coordinate efforts with undergraduate/graduate students and postdoctoral fellows in the lab. 10% - Stay updated on the latest advancements in cancer biology, bioinformatics and genomics research and present findings to internal teams and external stakeholders, while also publishing research outcomes and presenting at conferences. Additional Job Description Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required. If you like working with energetic enthusiastic individuals, you will enjoy your career with us! The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need. Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees Thank you for wanting to be part of the Medical University of South Carolina team. Whether you want to teach the next generation of health care leaders, innovate new business models, discover the next breakthrough or provide patient care, there's a role for you that fuels your passion and takes advantage of your skills. There are career opportunities available in academics, research, hospital medicine, physician practices and support services, from patient billing to IT. As an applicant, you can search jobs for all MUSC entities as well as search by category and location. MUSC attracts more than $250 million annually in research funding, making it the biggest magnet for biomedical, extramural research dollars of all institutions of higher learning in South Carolina. The Clinical and Translational Science Award (CTSA) Program aims to advance clinical and translational science to increase the speed at which new treatments become available to patients. MUSC Health, the clinical enterprise, operates a 750 bed medical center, which includes a nationally recognized Children’s Hospital, the Ashley River Tower (cardiovascular, digestive disease, and surgical oncology), Hollings Cancer Center (one of fewer than 70 elite National Cancer Institute designated centers), a Level I Trauma Center and the Institute of Psychiatry. In addition, there are more than 100 outreach clinics, hospital/health system affiliations, and telehealth sites. U.S. News & World Report placed us among the top one percent of all American hospitals, with 11 specialties in the top 50. The MUSC Medical Center is also one of only three Magnet® designated hospitals in South Carolina.

Responsibilities

The fellow will conduct integrated multi-omics, statistical, and bioinformatics analysis to understand how temporal hypoxia alters cancer cell resistance to therapy and related biological processes. Key duties involve analyzing complex datasets to identify novel biology, collaborating on actionable targets, and participating in career development and mentoring activities.