Visiting Jr. Researcher, Genetics for Host Defense at UT Southwestern Medical Center

Dallas, Texas, United States -

Full Time

Start Date

Immediate

Expiry Date

29 May, 26

Salary

0.0

Posted On

28 Feb, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Genetics, Host Defense, Computational Approach, Functional Impact Assessment, Genetic Variants, 5' Untranslated Region, Translation Initiation, Protein Expression, Sequencing Data Analysis, Pathogenic Variant Identification, Rare Genetic Diseases Diagnostics

Industry

Higher Education

Description

WHY UT SOUTHWESTERN? With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to U.S. News & World Report, we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you'll discover a culture of teamwork, professionalism, and a rewarding career! BENEFITS UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include: PPO medical plan, available day one at no cost for full-time employee-only coverage 100%25 coverage for preventive healthcare-no copay Paid Time Off, available day one Retirement Programs through the Teacher Retirement System of Texas (TRS) Paid Parental Leave Benefit Wellness programs Tuition Reimbursement Public Service Loan Forgiveness (PSLF) Qualified Employer Learn more about these and other UTSW employee benefits! EXPERIENCE AND EDUCATION Working on a terminal degree with 0 experience. JOB DUTIES The Center for the Genetics of Host Defense would like to hire a Postdoctoral Researcher for the laboratory of Jean-Laurent Casanova. This person will developed a novel computational approach to assess the functional impact of genetic variants in the 5' untranslated region (5' UTR), with a focus on variants that alter translation initiation and protein expression. Applying this method to patient sequencing data, identified a pathogenic 5' UTR variant in RPSA associated with reduced protein production and congenital asplenia, bridging basic and clinical research with implications for improved diagnostics of rare genetic diseases. SECURITY AND EEO STATEMENT Security This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information. EEO UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.

Responsibilities

The researcher will develop a novel computational approach to evaluate the functional impact of genetic variants in the 5' untranslated region, focusing on those affecting translation initiation and protein expression. This method will be applied to patient sequencing data to identify pathogenic variants linked to rare genetic diseases.