JOIN AMGEN’S MISSION OF SERVING PATIENTS

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

BASIC QUALIFICATIONS:

• Ph.D. with a deep understanding of structural biology and general biochemistry.
• Significant graduate research experience in large macromolecular complex structure determination. Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, structure determination and analysis.
• Expertise on cryo-EM single particle analysis to determine atomic resolution structures.
• Excellent presentation skills (written and oral) for effective team-based communication of results.
• Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment.
• Skills in managing multiple projects and capability to prioritize.

PREFERRED QUALIFICATIONS:

• Experience with immune biology and molecular basis of immunogenicity.
• Experience with innovative method development in protein biochemistry including protein rigidification, protein folding and TEM grid substrate derivatization, etc.
• Experience with other protein biochemical and/or biophysical characterization of protein complexes.

Let’s do this. Let’s change the world. In this vital role you will join the Structural Biology Department at our Research site in Burnaby, British Columbia, Canada. The Structural Biology laboratory provides comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across various therapeutic areas.

• Structure determination of target molecules in our large molecule and small molecule programs primarily using cryo-electron microscopy (cryo-EM). Experience in X-ray crystallography is a plus.
• Work closely with computational biologists and protein biochemists in the protein biochemistry group and protein design group.
• Collaborate with teams across various functions in the Therapeutic Discovery Research organization including Biologic Discovery, Discovery Protein Science, and Digital Biologics Discovery, to develop strategies toward therapeutic protein de-immunization.
• Participate deeply in the structural biology projects related to immunogenicity.