BASIC QUALIFICATIONS:

Doctorate degree and 6 years of relevant experience
OR
Master’s degree and 10 years of relevant experience
OR
Bachelor’s degree and 12 years of relevant experience

PREFERRED QUALIFICATIONS:

• PhD in Immunology, Biomedical Engineering, Vaccinology or Computational Systems Biology.
• Postdoctoral studies in related disciplines; antigen-processing, vaccine design, T and B cell epitope prediction, immune repertoire profiling.
• Hands-on experience with in vitro immunogenicity assays and in silico modeling tools
• Proven track record of integrating laboratory science and state-of-the-art machine learning protein design modeling tools to solve challenging protein design problems
• Experience working in the wet lab or directly with wet lab scientists
• Great communication abilities and meticulous attention to detail, including for written and oral presentation and code documentation
• Broad general interest in modeling complex biological systems
• Ability to drive an end-to-end project including working with collaborators to deliver results
• Desire to be part of a team that transforms objectives into tangible outcomes, propels numerous dynamic projects, and cultivates effective cross-functional partnerships

WHAT YOU WILL DO

Let’s do this. Let’s change the world. We have an opening for a Principal Scientist on our Large Molecule Discovery group, located at Amgen British Columbia. Our team specializes in the discovery of large molecules and the development of Predictive In vitro Biological Systems to evaluate the efficacy and safety of new candidate molecules.
You will lead translational efforts in protein design with a mission to eliminate or reduce immunogenicity in large molecule therapeutics. This pivotal role bridges experimental immunology and computational science to ensure novel biologics are safe and effective from the outset.

WHAT YOUR ROLE WILL BE

• To embed with our wet-lab teams and lead communication and drive collaboration between the computational data sciences and laboratory research teams.
• Leverage ground-breaking technologies to interrogate adaptive humoral and cellular immune responses
• Design experiments to test and validate novel immunomodulatory methods and compounds
• Develop strategies to direct the adaptive immune response towards desired outcomes
• Collaborate with protein engineers to create, test and optimize novel molecule designs
• Lead external collaborations with academic and industry partners to access emerging technologies in Immunoengineering and AI-driven protein design.
• Monitor and evaluate scientific advances relevant to adaptive immunity and therapeutic engineering to inform strategic R&D decisions.