YOUR FUTURE IN DETAIL

The University of Cologne is one of the largest and oldest universities in Germany. Our broad range of subjects, the dynamic development of our main research areas and our central location in Cologne make us attractive for students and researchers from around the world.
The Fenech lab is a recently established DFG-funded Emmy-Noether research group at the Center for Biochemistry Cologne, located on one of Europe‘s top research campuses with state-of-the-art facilities. We aim to understand why, in the eukaryotic secretory pathway, so many similar proteins function alongside each other. These similar machineries – called homologs – can ‘back each other up’ with shared functions. However, all of them also have important unique functions and features, and for most, we still don’t know what underlying molecular mechanisms define this specificity. To uncover these, we use a combination of high-throughput protein interactor profiling, cell biology and biochemical tools in baker’s yeast and mammalian cells to find unique regulators and/or clients of homologous machineries.
We are looking for two enthusiastic doctoral researchers that share our fascination of how the largest organelle in the cell – the endoplasmic reticulum (ER) – works.

• Designing, performing and analyzing proteomics experiments
• Building hypothesis-based theories and testing them using a range of different cell biology and biochemical techniques
• Handling and manipulating yeast whole-genome collections or patient-derived samples
• Preparation of figures and data for presentation at meetings and conferences, and writing reports, manuscripts and a PhD thesis dissertation