Postdoc Positions in Proteomics and Genomics at University of Copenhagen

at  Kbenhavns Universitet

Two highly attractive postdoctoral positions are available in the Choudhary group at the University of Copenhagen.

ABOUT THE GROUPS

The Choudhary lab is technically and internationally diverse and embedded in an excellent environment that supports high-quality research and encourages interdisciplinary collaboration. The Choudhary lab conducts research using interdisciplinary, state-of-the-art technologies, including quantitative proteomics, next-generation nucleic acid sequencing, advanced microscopy, CRISPR-based genome editing, and bioinformatics. The lab uses diverse cell models, including embryonic stem cells and their differentiated derivatives.
The group extensively collaborates with top-level international researchers, routinely publishes in top-ranked journals, and has an outstanding track record in training the next generation of researchers. The major publications from the groups include Prus et al. Cell 2024, Narita et al. Nat. Genet. 2023, Narita et al. Mol Cell. 2021, Narita et al. Nat Rev Mol Cell Biol 2019, Weinert and Narita et al. Cell 2018, Gupta et al. Cell 2018, Scholz et al. Nat Biotech 2015, Weinert et al., Mol Cell 2013, Povlsen and Beli et al. Nat Cell Biol 2012, and Beli et al. Mol Cell 2012.
We are now looking for enthusiastic postdocs with a PhD and/or MD (i.e. level of education corresponding to the Danish PhD degree).

PROJECT DESCRIPTION

Our group works in the broad area of proteomics, genomics, and cell signaling. In this project, we are interested in understanding the scope and function of lysine acetylation in gene regulation, as well as to understand the mechanisms of gene activation by cis-regulatory enhancers. Recently, group identified histone H2BNTac as a new signature of bona fide enhancers (Narita et al. Nat Genet 2023), and discovered principles of cell-type-specific quantitative variation in gene expression )Narita et al. https://www.biorxiv.org/content/10.1101/2022.07.18.500456v2). In the envisioned projects, we aim to use quantitative proteomics and genomics to further understand the role of acetylation and other chromatin modifications in gene regulation. The project will combine CRISPR-based genome editing with NGS-based approaches (i.e. RNA-seq, ChIP-seq, ATAC-seq) and cell biological approaches to uncover new regulatory pathways and decipher underlying mechanisms.
Depending on the candidate´s background, the postdoc candidate will either perform wet laboratory experiments involving cultured mammalian cells, CRISPR, and NGS-based genomic technologies, or proteomics technologies to generate large-scale datasets and to understand cellular regulatory mechanisms. Candidate with interest in data analysis is expected to perform bioinformatic analyses of next-generation sequencing data, including ChIP-seq, RNA-seq, Nascent-seq, and ATAC-seq. The candidates with experience in both wet lab and bioinformatics will be able to do both (i.e. work in the wet lab and perform bioinformatics analyses). If you would like to know more about the project(s), please contact us!
The postdoc position is funded by a newly funded ERC advanced grant (Oct 2024- Sept. 2029), with additional funding from Novo Nordisk Foundation.
Tentative start date: November 2024 or later. The start date can be negotiated.

QUALIFICATIONS

The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good interpersonal and communication skills.

• The candidate is required to have a PhD/MD level of education corresponding to the Danish PhD degree in natural or medical science.
• Excellent scientific track record, including at least one publication in a high-quality, peer-reviewed international journal. Pre-prints can be counted for fulfilling this requirement.
• Expert knowledge in one or more of the following areas is advantageous:
• Prior experience in the area of epigenetics, and gene transcription regulation.
• Hands-on experience in generating datasets for ChIP-seq, RNA-seq, ATAC-seq
• Hands-on experience in quantitative mass spectrometry for analyzing proteins, their modifications, and protein-protein interactions
• Hands-on experience in bioinformatic analyzing next-generation sequencing datasets, such as ChIP-seq, RNA-seq, ATAC-seq
• Experience in computer programming languages, such as R, PythonStrong background in the statistical analysis of large-scale data
• Experience in molecular biology techniques, including proficient use of CRISPR-based genome editing
• Good communication skills, both oral and written.
• An analytical aptitude for devising innovative scientific or technical solutions.

For further information, please contact Professor Chunaram Choudhary, email: chuna.choudhary@cpr.ku.dk

Please refer the Job description for details