Senior Research Associate/Scientist

at  Frontage Laboratories

Title: Senior Research Associate/Scientist
Location: Hayward, Ca (on-site)
Reports to: Group Leader ADME at Quintara Discovery, part of Global Drug Discovery Services at Frontage Labs
Classification: Full-time
Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

POSITION/JOB SUMMARY:

We are looking for a highly motivated Senior Research Associate or Entry level Scientist (DOE) to develop and conduct pre-clinical Absorption, Distribution, Metabolism, and Excretion (ADME) parameter determination assays to evaluate potential therapeutics. Assay requests range from standard screening assays used to determine ADME properties of pharmaceutical candidates to developing and validating definitive assays from scratch following literature review. Standard assays include solubility determination (kinetic and thermodynamic), tissue and enzyme stability (microsomes, hepatocytes, plasma, blood, etc), phenotyping, protein binding (RED, HTPB, and ultracentrifugation), permeability, tissue partitioning, enzyme/transporter substrate/inhibitor determination and many others. We also employ robotic automation, HPLC and LC-MS/MS-based data analysis to enable high throughput screening. This position works with an interdisciplinary team of DMPK scientists, pharmacologists, and analytical chemists. It is lab-based, collaborative, and client-facing. While delivering accurate, scientifically sound results is our priority, we pride ourselves in being exceptionally responsive and flexible for our clients, using creativity and efficiency to meet their drug discovery goals.

Roles & Responsibilities:

• Plan and run defined protocols for various 96-well and 384-well plate-based assays daily.
• Analyze results using in-house and client-developed templates.
• Identify and troubleshoot errors and assess validity of unexpected results.
• Help develop and establish new assays to address individual clients’ needs.
• Maintain and use cells in culture.
• Assist with preparing informal and formal protocols and reports.
• Discuss with colleagues and clients about experimental design and results.
• Maintain a lab notebook.
• Other duties, as assigned.

EDUCATION, EXPERIENCE & SKILLS REQUIRED:

• MS in cell biology, biochemistry, or related field. PhD preferred.
• 3+ (MS) or 0+ (PhD) years of related experience in the biotech, pharma, or preclinical CRO industry.
• Experience with cell culture, buffer preparation, HPLC, mass spectrometers, cellular assays, and handling tissues.
• Prior experience developing assays to assess compound properties and ADME/DMPK parameters.
• Previous experience in a discovery project is highly desired.
• Understanding of ADME screening processes would be helpful.
• Understanding of drug-drug interaction (DDI) determination and the ICH guidance would be helpful.
• Excellent organization, planning, and communication skills.
• Critical attributes: attention to detail, self-motivated, willingness to ask questions.
  Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

• Plan and run defined protocols for various 96-well and 384-well plate-based assays daily.
• Analyze results using in-house and client-developed templates.
• Identify and troubleshoot errors and assess validity of unexpected results.
• Help develop and establish new assays to address individual clients’ needs.
• Maintain and use cells in culture.
• Assist with preparing informal and formal protocols and reports.
• Discuss with colleagues and clients about experimental design and results.
• Maintain a lab notebook.
• Other duties, as assigned