Analytical Scientist - Media Development

at  Lonza

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

QUALIFICATIONS:

PhD Degree in Biology / Biochemistry / Biotechnology / Biomanufacturing or other related Life Sciences. Extensive industry experience (6+ years) in an analytical environment focused on protein chemistry.
Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.
People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference

ROLE PURPOSE:

We have an opportunity for an inventive, enthusiastic, motivated and experienced senior analytical protein chemist with extensive experience in analytical separation, characterization
and glycosylation analysis of biotherapeutic proteins to join our team of experts in cell culture media development and optimization as an Associate Principal / Principal Scientist and Team Lead in media analytics. This high-level scientific position requires extensive experience with different protein chromatography, separation methods and analysis of relevant protein critical quality attributes. The ability to analyze, interpret complex data, optimize and troubleshoot analytical methods applying a QbD approach would be highly desirable. Knowledge of mammalian cell cycle, metabolism, biochemistry and cell biology would be advantageous.
The incumbent will be responsible for oversight and execution of the scientific activities of the Media Analytics team, which will include elements of laboratory work, scientific review and coaching, project management, professional mentoring, technology scouting and driving implementation of new technologies within the Lonza network.
The Media Analytics team is a key component of Biologics Media R&D, a fast-growing multidisciplinary and dynamic group focused on innovation and innovative approaches to developing and optimizing new media formulations for the growth and production of biotherapeutic proteins from CHO cells.

KEY ACCOUNTABILITIES AND DUTIES:

PhD Degree in Biology / Biochemistry / Biotechnology / Biomanufacturing or other related Life Sciences. Extensive industry experience (6+ years) in an analytical environment focused on protein chemistry. Detailed knowledge and practical application of liquid chromatography (SEC, IEX, HILIC, HIC, RP, affinity), mass spectrometry (LC-MS, LC-MS/MS), other separation methods (icIEF, CE-SDS) for protein analysis, and QbD for method development. Thorough understanding of the state of the art technologies and its applications for protein analysis, including charge and size variant analysis, titer measurement, glycosylation analysis, product related impurities and protein characterization with different protein formats, eg. monoclonal, bispecific antibodies, fusion proteins and complex glycoproteins.
Knowledge of basic cell and molecular biology techniques is also highly desirable, i.e., mammalian cell culture, flow cytometry, Western blotting, RT-PCR, confocal microscopy etc. Technological background in mammalian cell line development and cell culture process development and experience with high-throughput small-scale bioreactors i.e., ambr15 and ambr250, would be advantageous.
Strong leadership and excellent communication and interpersonal skills with the ability to directly influence stakeholders in a scientific capacity, and to scope, design and deliver technical projects with defined success criteria under tight timelines. Proven ability to work effectively and collaboratively in cross-matrixed/functional teams and demonstrated ability to successfully complete complex projects and solve challenging problems. Resilience to setbacks with an ability to take calculated risks and motivate the team under challenging conditions.