Assistant Principal Scientist – Functional Genomics

at  Insmed EU Careers

Company Description:
Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.
Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.
Recognitions:

A CERTIFIED GREAT PLACE TO WORK

We believe our company is truly special, and our employees agree. In July 2023, we became Great Place to Work-certified in the U.S. for the third year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, and Best Workplaces for Millennials™ lists.

Summary: We are seeking a highly motivated and innovative lead cell and molecular biologist to join our growing target discovery research team. In this leadership role, you will leverage your expertise in functional genetic screening technologies to elevate our synthetic rescue target discovery platform. You will spearhead the development and implementation of cutting-edge functional genomic methods to identify and validate novel therapeutic mechanisms and targets of genetic diseases. Collaborating closely with interdisciplinary research teams - including experts in human genetics, bioinformatics, in vivo models, and various disease areas – you will play a pivotal role in our mission to translate scientific discoveries into groundbreaking therapeutics, advancing them from concept to clinic. Responsibilities: Responsibilities

• Provide technical leadership and drive experimental design and strategy across our CRISPR screening platform, ensuring the implementation of best practices and innovative approaches.
• Operate in a matrix work environment, assisting scientists in designing and executing complex pooled and arrayed functional genetic screening programs for target identification and validation across multiple therapeutic areas.
• Lead a team of technology development scientists to continuously enhance in-house functional genomics capabilities and capacity.
• Stay up to date with state-of-the-art cell biology and genome editing technologies through literature reviews, conference attendance, and engagement with external experts.
• Monitor the genome editing-related patent landscape and identify licensing requirements and patenting opportunities as technologies advance.
• Interpret experimental data, troubleshoot issues, and deliver high-quality data packages and comprehensive reports.
• Lead discussions and present data at internal and external meetings (including academic and commercial parties) to facilitate project progression.
• Provide effective line management and coaching while maintaining an active lab-based presence to drive hands-on experimental work.

Requirements

• PhD in cell and molecular biology, or a related field, with at least 5 years of postdoctoral or equivalent biopharma experience in functional genetics.
• Proven track record in designing and applying arrayed, pooled, and/or single cell CRISPR screening techniques in multiple cell models.
• Extensive experience and knowledge in mammalian cell culture, including the engineering of complex cell models, lentivirus packaging and transduction.
• In-depth knowledge of various CRISPR modalities, such as CRISPR-Cas9, CRISPR interference, CRISPR activation, base editing, and/or prime editing.
• Experience in sgRNA library design, optimization, and validation.
• Proficiency in developing and implementing high throughput phenotypic assays, including cell survival, flow cytometry, and high content imaging read-outs.
• Broad expertise in molecular biology techniques, including DNA/RNA/protein extractions, quantitative PCR, plasmid design, and molecular cloning.
• Familiarity with next-generation sequencing technologies, including library preparation and data interpretation.
• Self-starter with strong planning and problem-solving skills.
• Excellent team collaboration, communication, and presentation skills.
• Adaptable, with the ability to thrive in an empowering work environment.
• Proven experience in coaching and mentoring scientists
• Occasional tissue culture work on weekends.

Desirable

• Experience in CRISPR screening in iPSC-derived cell models and/or in vivo models.
• Experience with laboratory automation for high throughput screening.
• Knowledge of bioinformatics tools and statistical methods for functional genomic data analysis.
• Familiarity with drug discovery processes and therapeutic development for genetic diseases.
• Line management experience.

Travel Requirements:
N/A
Compensation & Benefits:
We’re committed to investing in every team member’s total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world.
Additional Information:
Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.
Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.
Applications are accepted until the position is filled

• Provide technical leadership and drive experimental design and strategy across our CRISPR screening platform, ensuring the implementation of best practices and innovative approaches.
• Operate in a matrix work environment, assisting scientists in designing and executing complex pooled and arrayed functional genetic screening programs for target identification and validation across multiple therapeutic areas.
• Lead a team of technology development scientists to continuously enhance in-house functional genomics capabilities and capacity.
• Stay up to date with state-of-the-art cell biology and genome editing technologies through literature reviews, conference attendance, and engagement with external experts.
• Monitor the genome editing-related patent landscape and identify licensing requirements and patenting opportunities as technologies advance.
• Interpret experimental data, troubleshoot issues, and deliver high-quality data packages and comprehensive reports.
• Lead discussions and present data at internal and external meetings (including academic and commercial parties) to facilitate project progression.
• Provide effective line management and coaching while maintaining an active lab-based presence to drive hands-on experimental work