Assistant principal scientist

at  Insmed EU Careers

Company Description:
Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.
Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.
Recognitions:

A CERTIFIED GREAT PLACE TO WORK®

We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists.

Summary: We are seeking an innovative and self-driven medicinal chemist to join our dynamic chemistry team, contributing to the advancement of our drug design strategies. This role is pivotal in supporting the design and synthesis of novel molecules to translate our groundbreaking biological discoveries into medicines. It presents an outstanding opportunity to thrive within an exciting, next-generation therapeutics environment. The work pace is dynamic, swift, and engaging. Responsibilities: Key Responsibilities

• Innovative Design: Support the design of novel molecules, leveraging cutting-edge in-silico and synthetic techniques to drive drug design. Apply efficient and effective methodologies to complete hit-to-candidate medicinal chemistry campaigns to the highest standards and in short timescales
• Organic Synthesis: Plan and manage organic synthesis activities, ensuring efficient execution and optimization of synthetic routes. Assist in establishing safe and effective working practices in company laboratories.
• Carrying out synthetic procedures on milligram and gram scale to support compound synthesis.
• Working closely with other chemists and stakeholders to maximize the overall effectiveness of synthetic campaigns.Troubleshooting issues in the laboratory.
• Process Development: Contribute to the development and implementation of departmental processes that enhance efficiency and streamline operations, critical for a fast Design-Make-Test-Analyze (DMTA) cycle. Be aware of external technology developments and opportunities for collaboration to enhance the development of company capabilities
• CRO Management: coordinate activities with external CROs, ensuring the highest quality and timely delivery of project milestones.
• Cross-functional Collaboration: Work closely with cross-functional teams, including biology, pharmacology, and ADME, to integrate multidisciplinary insights into cohesive project plans.
• Project Leadership: Support medicinal chemistry projects from concept to clinic, ensuring alignment with overall program goals and timelines. Present and contribute to internal company scientific and strategic review panels
• Team Development: Manage and mentor a team of skilled chemists, fostering a collaborative and innovative environment.
• Scientific Excellence: Identify opportunities to publish chemistry-related company results.

Required:

• A PhD in organic chemistry
• 5+ years’ experience in a medicinal chemistry role within biotech or pharma
• Theoretical and practical synthesis knowledge with strong problem-solving skills
• Demonstrated flair for structure-based drug design and data analysis (SAR) to tackle typical medicinal chemistry challenges including ADME and physicochemical properties.
• Demonstrate impact on drug discovery projects (design and or synthesis) to successful outcomes.
• Experience carrying out small molecule synthesis and interpretation of analytical methods for chemical characterization.
• Strong verbal and written communication skills
• A strong sense of urgency and focus to deliver successful outcomes
• Up to date awareness of latest technology developments in drug design, synthesis and testing
• Demonstrated ability to mentor and develop scientists
• Significant track record of publications and patents

Additonal skills: ELN, Data management, Knime, Data visualisation/analysis (Spotfire, Vortex) Travel Requirements:
N/A
Compensation & Benefits:
We’re committed to investing in every team member’s total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world.
Additional Information:
Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.
Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.
Applications are accepted until the position is filled

• Innovative Design: Support the design of novel molecules, leveraging cutting-edge in-silico and synthetic techniques to drive drug design. Apply efficient and effective methodologies to complete hit-to-candidate medicinal chemistry campaigns to the highest standards and in short timescales
• Organic Synthesis: Plan and manage organic synthesis activities, ensuring efficient execution and optimization of synthetic routes. Assist in establishing safe and effective working practices in company laboratories.
• Carrying out synthetic procedures on milligram and gram scale to support compound synthesis.
• Working closely with other chemists and stakeholders to maximize the overall effectiveness of synthetic campaigns.Troubleshooting issues in the laboratory.
• Process Development: Contribute to the development and implementation of departmental processes that enhance efficiency and streamline operations, critical for a fast Design-Make-Test-Analyze (DMTA) cycle. Be aware of external technology developments and opportunities for collaboration to enhance the development of company capabilities
• CRO Management: coordinate activities with external CROs, ensuring the highest quality and timely delivery of project milestones.
• Cross-functional Collaboration: Work closely with cross-functional teams, including biology, pharmacology, and ADME, to integrate multidisciplinary insights into cohesive project plans.
• Project Leadership: Support medicinal chemistry projects from concept to clinic, ensuring alignment with overall program goals and timelines. Present and contribute to internal company scientific and strategic review panels
• Team Development: Manage and mentor a team of skilled chemists, fostering a collaborative and innovative environment.
• Scientific Excellence: Identify opportunities to publish chemistry-related company results