Associate Scientist I/II (Contractor), In Vivo Discovery

at  GentiBio

GentiBio is seeking a collaborative and motivated Associate Scientist I/II Contractor to join our Discovery team in Cambridge, MA. The successful candidate will design, optimize and execute in vivo studies to characterize engineered T regulatory (EngTreg) cells to support our early-stage programs. This role offers exposure to leadership and an exciting opportunity to be a high-impact trailblazer in the emerging field of regulatory T-cell therapy.

QUALIFICATIONS & EDUCATION

• BS or MS in related field with 2+ years of relevant industry or academic experience.
• Confident with the routine handling of animals and experience with mouse models and techniques is a must (e.g. tail vein or intraperitoneal injection)
• Experienced in or willing to learn primary cell culture, flow cytometry, and ELISA
• Strong attention to detail and demonstrated ability to execute experiments with rigor and maintain clear and complete records of lab work
• Evidence of critical thinking and the ability to devise a plan beyond the immediate experiment
• Exceptional teamwork and communication skills with the ability to embrace change and multitask in a fast-growing environment
  About us: GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. We are focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics. Our corporate operations are in both Cambridge, MA and Seattle, WA.
  We are building an exceptional company culture focused on empowerment, care for one another, an appreciation for diversity and inclusion, and the development of our people. We are looking for people who are not only incredible experts in their field, but also individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so
  EEO Statement: GentiBio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
  Recruitment & staffing agencies: GentiBio does not accept agency resumes unless contacted directly by internal GentiBio Talent Acquisition. Please do not forward resumes to GentiBio employees or any other company location; GentiBio is not responsible for any fees related to unsolicited resume

• Collaboratively design and implement murine models of inflammatory and autoimmune disease for the testing of EngTregs
• Independently dose, closely monitor, and care for animals in experimental studies
• Perform terminal evaluations of murine experiments, including tissue digestion, histology preparation, multicolor flow cytometry, and ELISA
• Track and compile results in an electronic notebook
• Contribute to editing (e.g., CRISPR and viral transduction) and culture EngTregs in vitro from primary cells
• Support the evaluation of phenotype and functionality of CAR EngTreg cell constructs by a variety of assays using multicolor flow cytometry
• Utilize Excel, PowerPoint, GraphPad Prism, Flowjo, and ELN for data entry, analysis, and presentation
• Communicate and present findings to scientific team and management
• Foster the culture of seeking and giving help, inclusion, authenticity, and fun