Guillaume Research Associate

at  University of Sheffield

An exciting opportunity has arisen for a Research Associate to join the Sheffield Institute for Translational Neuroscience (SITraN) on a pre-clinical translational research project. SITraN is a purpose-built research facility which was opened in November 2010 by Her Majesty the Queen and awarded the Queen’s Anniversary prize for higher education in 2020 in recognition of having made an outstanding positive impact in patient’s lives. The Institute houses clinical and basic scientists researching neurodegenerative disorders including Motor Neurone Disease (MND), Parkinson’s and Alzheimer’s.
You will join a dynamic research team under the supervision of Professor Guillaume Hautbergue with a focus on developing SRSF1-based genetic therapies in pre-clinical models of C9orf72-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This work will involve working with viral gene therapy vectors and antisense oligonucleotide or siRNA approaches to inhibit the SRSF1-dependent nuclear export of pathological repeat transcripts in cell and mouse models of C9orf72-ALS/FTD. The successful candidate will have a strong background in Neuroscience and a significant experience of histopathology techniques and handling of neurodegenerative mouse models. Experience of working with ALS models and in vitro tissue culture skills would also be desirable. A passion for research into neurodegenerative diseases and track record of research experience in Neuroscience is an advantage. Team spirit and an impeccable work ethic are essential.
We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.
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