Investigative Toxicology: Research Associate, Predictive and Investigative

at  Vertex Pharmaceuticals

Job Description:

INVESTIGATIVE TOXICOLOGY: RESEARCH ASSOCIATE, PREDICTIVE AND INVESTIGATIVE SAFETY ASSESSMENT, SAN DIEGO

Vertex Pharmaceuticals uses cutting edge science and technologies to create transformative therapies for the treatment of the most serious diseases with unmet medical need. Our culture enables individual empowerment where “We Wins” “Fearless Pursuit of Excellence” and “Innovation” are more than just corporate values: They are part of our everyday lives.
Preclinical Safety Assessment is a global function responsible for the design and execution of preclinical strategies for the comprehensive safety assessment of Vertex therapies at all stages of discovery and development, beginning in the early drug discovery phases and continuing through the entire drug development value chain resulting in registration and marketing.
The Predictive and Investigative Safety Assessment (PISA) group is seeking exceptional candidates to assist with the execution of complex in vitro cell-based toxicology models to assess the safety profile of drug candidates prior to clinical testing. The successful candidate will be able to thrive in a fast-paced environment with minimal supervision. As part of this work, the candidate is expected to perform primary cell and cell line culture, execute imaging and plate reader-based assays, run qPCR and western blots, and collect and analyze datasets. This is a lab-based position that is an integral part of the preclinical safety team. We are looking for a technically proficient individual with a life sciences background who has previous experience with cell-based assays in an academic or industry setting.
6 month contract starting mid November

Summary of Responsibilities:

• Execute in vitro cell-based phenotypic assays in a timely manner.
• Perform western blots or qPCR for mechanistic understanding of phenotypic changes.
• Examines data, performs quantitative analysis, and thoroughly documents findings.
• Prepares reports and presentations as needed.
• Presents data to preclinical safety team.

Minimum Qualifications:

• S. or M.S. in life sciences with a minimum of 2 years of relevant research experience in an academic or industry setting.
• Experience with established cell lines, primary cell culture, and sterile techniques.
• Experience with fluorescence microscopy, qPCR, and western blots.
• Excellent multi-tasking skills, attention to detail and ability to work independently are required.
• Ability to analyze datasets using GraphPad Prism and maintain detailed records.
• Strong written and oral communication skills.
• Experience working in a team setting.

Pay Range:
$33-$35/HR
Requisition Disclaimer:
This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements
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• Execute in vitro cell-based phenotypic assays in a timely manner.
• Perform western blots or qPCR for mechanistic understanding of phenotypic changes.
• Examines data, performs quantitative analysis, and thoroughly documents findings.
• Prepares reports and presentations as needed.
• Presents data to preclinical safety team