Laboratory Animal Technician

at  Fusion Pharmaceuticals US Inc

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion’s growing pipeline of RCs.
Fusion is seeking outstanding applicants for a Laboratory Animal Technician to support a broad range of preclinical drug development activities. This position is lab-based, and located in Hamilton, Ontario, Canada.

QUALIFICATIONS:

• Recognized post-secondary education in the health or veterinary sciences.
• Bachelor’s degree in Science, Health Sciences, Animal Sciences, Engineering, or a related field is preferred.
• Greater than 2 years of experience working in laboratory animal experimentation, animal care, and animal laboratory operations.
• CALAS (Canadian Association of Laboratory Animal Science) certification is an asset.
• Expertise in the administration of test articles to rodents by intravenous injection and gavage is required.
• Experience with mammalian cell culture, experience with general biochemical methods (e.g., protein quantification, ELISA, SDS-PAGE and immunoblotting, UV/VIS spectroscopy) and cell biological methods (eg. flow cytometry, immunohistochemistry) is an asset.
• Highly organized with proven ability to work independently with strong communication skills
• Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels.
• Experience with the safe handling of radioactive and biohazardous materials/waste.
• Willingness to take on new tasks and responsibilities as required.
• Ability to thrive in a fast-paced, dynamic environment and manage multiple priorities simultaneously.
  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

• Conduct and report on therapeutic efficacy and biodistribution studies of radiopharmaceuticals using rodent models of cancer (or other disease indications of interest)
• Maintain rodent cohorts (including husbandry, tumor measurements, tissue sample collection, and endpoint monitoring), establish tumour xenografts, and administer test articles to rodents by various routes including injection and oral gavage
• Perform mammalian cell culture in support of biology group activities
• Document experimental procedures and results in an electronic notebook system
• Assist in the maintenance of laboratories, animal facilities, and laboratory equipment
• Maintain laboratory records (SOPs, SDS, chemical, radioisotope, biohazard, cell bank)
• Other duties as required