Lead Researcher in 2-Photon Imaging in Schizophrenia Models - Zakharenko Lab

at  St Jude Childrens Research Hospital

A Lead Researcher position is available for a highly motivated individual interested in transitioning from a postdoctoral position to a more stable staff scientist position.
The successful candidate will lead an independent research project dedicated to identifying abnormal neuronal circuits in murine models of 22q11.2 and 3q29 deletion syndromes, 2 rare conditions that confer the highest genetic risks of schizophrenia.
Preference will be given to applicants who have a strong background in 2-photon imaging of restrained experimental subjects, cranial window surgeries, in vivo stereotaxic-guided injections of viruses, and strong communication skills. The laboratory is equipped with 2 dedicated 2-photon mesoscopes (Thorlabs) and Mini-2p (Thorlabs) and Inscopix miniature microscopes for imaging large cortical areas and subcortical structures at cellular and subcellular resolution in awake, behaving organisms (Chun et al, Science 2014; Blundon et. al. Science 2017; Davenport et al., Cell 2022; Bayazitov et al., Cell Reports 2024).
The candidate also will benefit from an outstanding, highly collaborative work environment in which a diverse team of 12 researchers is focusing efforts toward understanding the mechanisms of schizophrenia and psychotic behavior at the levels of neural circuits and individual neurons, synapses, and molecules.
The Zakharenko laboratory is part of the Department of Developmental Neurobiology, which houses specialized departmental shared resources, including an integrated support structure for behavioral phenotyping, genetic engineering, in vivo and ex vivo neuroimaging, computational neuroscience, and single-cell genomics. In addition, numerous institutional shared resources and core facilities support the laboratory by providing expertise and state-of-the-art technologies.

MINIMUM EDUCATION AND/OR TRAINING:

• Bachelor’s degree in relevant scientific area is required.

MINIMUM EXPERIENCE:

• Five (5) years of relevant, post-degree work experience is required
• Two (2) years of relevant post-degree work experience is required with a Master’s degree
• No experience is required with a PHD
  St. Jude Children’s Research Hospital offers an excellent salary and benefits package and is an equal-opportunity employer.
  Interested applicants should send their CVs and the names and addresses of 3 references to:
  Stanislav Zakharenko, M.D., Ph.D. Department of Developmental Neurobiology, MS 322
  St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN 38105
  stanislav.zakharenko@stjude.org

• Performs laboratory experiments using existing, modified or newly developed techniques/protocols
• Sets up protocols, trouble shoots experiments using new or modified laboratory techniques
• Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data and reports results
• May assist in the drafting and editing of manuscripts.
• Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory and orders lab supplies as needed. Performs calibration of instruments and equipment as necessary.
• Provides guidance to entry-level employees.
• Performs other related duties as assigned in order to meet the goals of the department and institution
• Maintains regular and predictable attendance