Manufacturing Scientist (Cell and Molecular Biology Products)

at  ANGLE Plc

ABOUT ANGLE:

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.
ANGLE’s Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patients tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.
ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.

JOIN OUR TEAM:

This is an exciting time at ANGLE and our team in Guildford are looking for a Manufacturing Scientist (Cell and Molecular Biology Products) to play a key role in the production process with a focus on manufacturing and assembly of finished products, performing quality checks, fulfilling manufacturing instructions and carrying out the therein-described procedures. The job is laboratory-based, working in a multi-disciplinary team.
At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.
We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

QUALIFICATIONS, EXPERIENCE, KNOWLEDGE AND ATTRIBUTES:

• B.Sc. or equivalent in Life Sciences related to Cell Biology, Oncology or Molecular Biology, with at least 3 years of post-graduate laboratory experience gained in manufacturing for the in vitro diagnostics industry (or an equivalent combination of experience and formal education).
• The role requires exceptional experience with manipulating and enumerating mammalian cells and accurately aliquoting antibody and oligo suspensions (using pipetting and fluorescence microscopy).
• Experience working to strict quality standards such as Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP, QSR. A strong understanding of the importance of accurate record keeping within a strictly controlled quality system is essential.
• Organisational skills and the ability to follow agreed procedures are essential.
• Managing and delivering production to agreed timetables and according to defined instructions.
• Good report writing skills, with the ability to communicate results to technical and non-technical staff.
• Strong verbal and written communication skills.
• Ability to multitask and prioritise to meet deadlines.
• Ability to work both independently with minimal supervision as well as in a team environment.
• Continuous learner with a keen appetite for cross-disciplinary work.
• A flexible, can-do approach to the requirements of the job.
• Entrepreneurial thinking and work ethic.
• An eye for detail and commitment to high-quality data.

JOB REQUIREMENTS:

Due to the nature of the role, our requirement is for this position to be Guildford-based, office hours, five days per week.
As a member of our highly skilled team you will receive opportunities for training and development and a competitive benefits package.
Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.
Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.

• Hands-on laboratory bench work, primarily in the area of manufacturing cell-based and molecular biology-based products.
• Setting up, operating, and maintaining manufacturing equipment.
• Performing specific tasks in the laboratory (manufacturing area) that may include the manufacture or packing of the finished product.
• Conducting inspections and tests to ensure products meet quality standards and specifications.
• Generating and maintaining accurate manufacturing documentation, undertaking stock control and ensuring the release of manufactured products through manufacturing batch record approvals.
• Identifying and resolving issues with equipment or production processes to minimise downtime.
• Participate where assigned in the timely resolution and maintenance of any manufacturing-related CAPAs and defects.
• Responsible for quality and regulatory compliance of work undertaken.
• Provide additional ad-hoc scientific and technical support to manufacturing processes, R&D programmes and projects.
• Deputy for Manufacturing Supervisor during the holiday period.
• Undertake additional ad-hoc tasks as required.