Medical Laboratory Technologist, Genetics

at  Mount Sinai Hospital

COMPANY

Mount Sinai Hospital
The Diagnostic Medical Genetics Laboratory at Mount Sinai Hospital is a hub for cutting-edge diagnostic testing and innovative method and test development. We are dedicated to improving patient care through a deeper understanding of genetics. Equipped with advanced technologies, the lab offers a wide range of genetic and genomic testing, supporting diverse clinical needs across various specialties. A collaborative spirit thrives within the lab, bringing together a team of skilled professionals, including geneticists, genetic counselors, variant analysts, bioinformaticians, medical laboratory technologists and technicians. This team is united by a shared passion for unraveling the complexities of genetic disorders, pioneering new diagnostic and therapeutic approaches, and ultimately, making a tangible difference in the lives of patients and their families.

REQUIREMENTS

Job Requirements:

Mandatory

• Canadian Society for Medical Laboratory Science (CSMLS) certified MLT in Cytogenetics and Molecular Genetics Technology (Dual License)
• Member of the College of Medical Laboratory Technologists of Ontario (CMLTO)
• Candidates eligible to write the upcoming Clinical Genetics CSMLS exam will be considered

Preferred

• Experience in Medical Genetics

Skills and Knowledge

• Demonstrated problem recognition and problem solving skills
• Demonstrated organizational, time management and prioritization skills
• Demonstrated satisfactory work performance and attendance record
• In accordance with accreditation standards, employment is conditional upon demonstrating proof of visual colour discrimination ability pertinent to the essential duties of the job.

In this role you will:

• Perform Molecular and Cytogenetics procedures as outlined in the laboratory standard operating procedures to aid in diagnosis and management of patients.
• Rotate through the laboratory testing benches, becoming thoroughly familiar with theory and performance of all procedures and techniques relating to each bench area
• Identify and accurately report cytogenetic findings using the International System for Human Cytogenetic Nomenclature
• Ensure the accuracy, legibility and completeness of results submitted for reporting where applicable
• Perform all quality control procedures and basic troubleshooting whenever results are beyond expected or allowable limits according to established protocol
• Accession and process specimens in accordance with Standard Operating Procedures (SOPs)
• Prioritize work and respond to urgent or unpredicted demand for specimen processing or testing
• Prepare reagents, buffers, calibrators, quality control and other materials as required. Assist in inventory control of reagents and supplies
• Perform test/procedures related to method evaluation, test optimization and validation
• Observe and follow the processes, policies and procedures of the quality management system of corresponding discipline(s)
• Assist in orientating and demonstrating procedures or technology to new staff or students as requested
• Perform the following techniques as applicable to the testing being performed and interpret results with an understanding of the disease being analyzed:

o Next Generation Sequencing (NGS) and Sanger Sequencing, including library preparation and analyses
o DNA extraction from fresh or frozen blood, fresh, frozen or paraffin-embedded tissue
o RNA extraction from fresh or frozen blood, fresh or frozen tissue
o Polymerase Chain Reaction (PCR)
o Quantitative fluorescent polymerase chain reaction (QF-PCR) techniques and analysis
o Gel electrophoresis and analysis
o Microsatellite Instability Testing (MSI) techniques and analysis
o Multiplex Ligation-dependent Probe Amplification (MLPA) techniques and analysis
o Microarray techniques and analysis
o Special stains, FISH and other procedures as required
 Microscopic (bright field & fluorescent) analysis of chromosome preparations
o G-Banding, digital imaging and computer automated karyotyping of chromosome preparations