MRC Postdoctoral Research Scientist LMS 2479

at  Medical Research Council

Open Date
09/08/2024, 00:00
Close Date
30/09/2024, 23:55
Research Institute
MRC Laboratory of Medical Sciences
Research Institute / Unit Information
The LMS is a world-class research laboratory where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation, the LMS has a collaborative working culture and new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus (W12).
The LMS aims to deliver transdisciplinary team science, in synergistic interaction with Imperial College and the wider national research environment. Part of achieving this, is to recruit new talent and support postdoctoral scientists to become world leaders in their area of science.
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org
Band

MRC - 4

Location
London
Salary
£39,375 plus London allowances (£3,913 & £1,472) per annum
Allowances
Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.
Contract Type
Fixed Term
Job Type
Science
Full Time / Part Time
Full Time
Contract Length
3 years
Job Description

EDUCATION / QUALIFICATIONS / TRAINING REQUIRED (WILL BE ASSESSED FROM APPLICATION FORM):

Essential:

• PhD or equivalent experience

Previous work experience required (will be assessed from application form and at interview):

Essential:

• Experience in human or mouse genetics, cell and molecular biology, human iPS / ES cell culture / differentiation or functional genomics is essential

Desirable:

• Expertise in the biology of cohesin / CTCF and computational skills would be a substantial advantage

Knowledge and experience (will be assessed from application form and at interview):

Essential:

• Ability to develop and apply new concepts
• Ability to independently carry out experimental and / or computational projects and analyses
• Creative approach to problem solving
• Good understanding of computational biology methods
• Great attention to details
• Good written communication skills in English

Personal skills / Behaviours / Qualities (will be assessed at the interview):

Essential:

• Ability to work independently and as part of a team and the ability to deal with a wide range of people
• Good oral communication skills in English
• Ability to constructively engage in scientific discussions
• Critical evaluation of data

Further Information
This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs for applicant (100% visa and 100% Health Surcharge) and immediate dependents (100% visa and 50% health surcharge when applying with main applicant) can be reclaimed from LMS after taking up the post (terms and conditions apply).
Applicants should submit a CV, a brief cover letter describing scientific interests and names and contacts of two scientific references. Please quote reference number LMS 2479.

OVERALL PURPOSE:

A new opportunity has arisen for a 3 Year Postdoctoral Research Scientist to work in the Lymphocyte Development group headed by Professor Matthias Merkenschlager. This position is expected to be filled by the successful candidate from December 2024.
This project will focus X-linked competition, a newly discovered process by which X-chromosome sequence variation alters organismal development and skews the expression of X-linked sequence variants in a cell-type-specific manner (Buenaventura et al., 2024, Nature Genetics, published online 26th July, DOI 10.1038/s41588-024-01840-5). X-linked competition is unique to XX individuals and appears distinct from other known forms of cell competition that eliminate unfit cells from the developing organism

MAIN RESPONSIBILITIES:

• To plan and carry out research
• To write and publish the results
• To form good working relationships with other members of the group
• To assist others and co-supervise students when required
• To contribute to the development and maintenance of the group’s experimental or computational infrastructure as appropriate
  Person Specification