MSAT Scientist

at  SGVECTOR PTE LTD

ABOUT THE JOB

SGVector Pte. Ltd. is looking for a highly motivated Upstream Scientist to join our MSAT team. The successful candidate will play a critical role in the production and analysis of viral vectors to SGVector’s pipeline of cell and gene therapy products. The incumbent will be responsible for various aspects of development and production of recombinant viral vectors, streamlining operational workflows, and defining process and analytical improvements in alignment with the operational vision of SGVector.

REQUIREMENTS:

• Bachelor, Master degree or PhD in Chemical Engineering, Pharmaceutical Engineering, Biomedical Engineering, Molecular Biology, Biochemistry, Biotechnology or related fields, with 2-4+ years of relevant industry experience in biologics development and/or GMP manufacturing.
• Direct experience with mammalian cell expression technology and media optimization, using suspension-based bioreactor systems is required.
• Experience working in a BSL-2 environment and using aseptic techniques.
• Highly motivated team player with an ability to be productive and a willingness to learn in a fluid, fast-paced and environment are essential.
• Excellent organizational and collaborative skills, with the ability to design and troubleshoot experiments with minimal supervision or as part of a group.

• Perform plasmid cloning, amplification, and purification.
• Maintain mammalian cell cultures using aseptic techniques.
• Utilize DoE methodology to optimize cell growth and viral vector production in suspension mammalian cell cultures.
• Set-up and operate benchtop and large-scale single use bioreactors (50L).
• Perform molecular biology and analytical assays such as flow cytometry, ELISA and qPCR.
• Draft and edit lab protocols, standard operating procedures, sampling plans, technical reports, and batch records for regulatory or tech transfer purposes.
• Search literature for methods, processes, and assess new equipment and technologies in order to expand and improve upstream capabilities.
• Collaborate with team members to identify and evaluate process improvements with the goal of optimizing the current viral vector production and purification process.