PAT Manager

at  Thermo Fisher Scientific

We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. With $1.4 billion invested annually in R&D, our collaborative and diverse teams have the resources they need to drive new discoveries and do cutting-edge research and develop important applications and tools that help millions of lives around the world.

JOB DESCRIPTION

As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world’s toughest challenges, like protecting the environment, making sure our food is safe or helping find cures for cancer.
Location: Greenville, NC

EDUCATION

• Masters or PhD in Analytical Chemistry, Chemical Engineering or related scientific field.

EXPERIENCE

• PhD with 3+ years of experience in PAT method development for pharmaceutical drug products. M.S. with 5+ years of experience in PAT method development for pharmaceutical drug products.
• Experience in applying at-line, on-line and in-line PAT methods for product and process insight, supporting development and manufacturing.
• Experience in Chemometrics and innovative multivariate modeling across spectroscopic techniques.
• Proven track record to manage and lead professional staff.
• Direct experience with or overall process understanding of continuous manufacturing is a plus.

KNOWLEDGE, SKILLS, ABILITIES

• Strong understanding of using spectroscopic techniques (e.g., FTIR, NIR and Raman) to develop method for process understanding and process control.
• Proficient in MATLAB programming and commercial Chemometrics software package such as Unscrambler and PLS toolbox.
• Strong statistical knowledge and capabilities.
• Excellent written and verbal communication, as well as interpersonal skills are essential. Comfortable working in multi-functional teams and providing professional contribution in process analytical technologies.

Act as an SME for Spectroscopic PAT method development, validation, implementation, revalidation and model maintenance. Design and implement experiments to supervise product quality and achieve process understanding to achieve the analytical target profile (ATP). Perform in-depth data analysis of PAT and continuous manufacturing process data for process insight, investigations and trending. Apply expertise to advance understanding of the science related to PAT across the organization. Work directly with clients to deliver on project goals and ensure customer and regulatory requirements are met. Collaborate with the Thermo Fisher organization to contribute to instrumental innovation.
Provides leadership to assigned staff. Defines resource needs (capital, expense, and headcount) so that current and future development PAT needs are met. Recruits, hires, retains, trains, and motivates a scientifically proficient staff. Provides opportunities for staff career development.