PhD candidate 'RNA biology and host defense in vector mosquitoes'

at  Radboudumc

4 years For a European Research Council (ERC)-Advanced Grant funded project, we are looking for two highly motivated PhD candidates to dissect the role of the piRNA pathway in antiviral defense. Moreover, we are interested in exploring whether the piRNA pathway can be harnessed for practical applications. Are you the PhD candidate with hands-on experience with a range of molecular biology / cell biological techniques we are looking for?

Aedes mosquitoes transmit important human pathogenic viruses, like Dengue, Zika and Chikungunya virus as well as a diverse set of insect-specific viruses. These viruses need to overcome the mosquito immune response to ensure their transmission. PIWI-interacting RNAs (piRNAs) are a class of regulatory RNA molecules that are essential for life. The PIWI gene family is a rapidly evolving gene family that has greatly expanded in Aedes mosquitoes, suggesting new functions compared to animals with a more restricted set of PIWI genes. The piRNA pathway has been implicated in antiviral defense and control of transposable elements in mosquitoes, but its in vivo importance remains to be established. At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.017 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.824 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• 172 vacation hours per year based on a 36-hour working week. (As of 1 January 2025, you will receive 176 vacation hours.)
• An Employment Conditions Selection Model, allowing you to use part of your employment conditions to your choosing. For example, you can use your gross salary to purchase additional vacation hours or hours for providing informal caregiving. Or, for example, you can use your gross end-of-year bonus to purchase a bicycle, so you pay less tax.
• Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment.
• Your well-being and vitality are a priority. For example:
• Save time for work-life balance leave.
• A 40% discount on a sports membership of the Radboud Sports Center.
• Healthy Professionals program to help you manage your energy.
• Company Support Team and a personal coach if you are going through a life-changing event.
• Financially beneficial working less through a Generation Scheme as you approach state pension age.
• Support in achieving a good work-life balance at every stage of your life. Examples:
• Advice and courses on, for example, ‘Millennial dilemmas’ and ‘Your Career After 57’.
• Activities at our own mindfulness center.
• Informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
• In addition to statutory pregnancy and maternity leave, Radboud university medical center offers 26 weeks of parental leave, nine of which are paid. In addition, as a partner you can take a maximum of five weeks of supplementary partner leave. During supplementary partner leave and parental leave, we supplement the UWV benefit up to 100% of your salary.
• Pension accrual at the ABP Pension Fund. Radboud university medical center pays 70% of the pension premium.
• Discounts on supplementary packages of two group health insurances and ten other types of insurance, from home insurance to legal assistance.
• As of 1 October 2024: an allowance for your commuting costs of € 0.18 per km up to a maximum of 40 km one way. If you use public transport to commute, we will fully reimburse the public transport costs (2nd class). If you regularly work from home, you will receive a working from home allowance of € 2.35 per day.

You will work in the Laboratory of Experimental Virology in the department of Medical Microbiology of Radboud University Medical Center under supervision of Prof. Ronald van Rij. The laboratory is affiliated with the Research Institute for Medical Innovation (RIMI), which provides an excellent environment for innovative science and offers access to state-of-the-art core facilities, including cellular imaging, proteomics, and genomics.
As a PhD student, you will be enrolled in the RIMI PhD program, offering advanced training through courses, lecture series, and symposia.The project is part of a European Research Council (ERC) Advanced Grant-funded project, which involves multiple PhD students/postdocs working on complimentary projects. We are dedicated to provide a social, dynamic, and stimulating work environment. Please visit Van Rij Lab for more information.

Please refer the Job description for details