PhD in co-translational protein structure prediction and probing

at  Universit du Luxembourg

The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character.
The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg.
We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary, and together we contribute to science and society.

The Gene Expression Dynamics junior group is looking for a highly motivated biochemist or RNA biologist with expertise in the analysis of nascent protein structures that are formed co-translationally. The candidate should have experience in state-of-the-art biochemical methods with a special focus on translation assays such as polysome and ribosome profiling, limited proteolysis, translationally competent extracts. In addition, the candidate should have a solid background in bioinformatics including analysis of large scale data (Ribo-seq, RNA-seq, mass spec) using statistical methods as well as structural machine learning algorithms such as AlphaFold. The candidate will perform and integrate kinetic ribosome profiling with structure prediction and biochemical structure probing experiments to identify proteins that are co-translationally folded.
For further information, please contact: Rico Schieweck - r.schieweck@googlemail.com