PhD student (f/m/d)

at  Uniklinik RWTH Aachen

Job-Benachrichtigung per E-Mail
Stellenangebote
The Clinic for Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine (Medical Clinic III) -research group Professor Dr. Pavel Strnad- has an opening for a

1. INVESTIGATING THE ROLE OF PATIENT-DERIVED IMMUNE CELLS IN ALPHA1-ANTITRYPSIN DEFICIENCY (AATD)

Alpha1-antitrypsin deficiency (AATD) is a genetic disorder characterized by mutations in the alpha1-antitrypsin (AAT) gene that predominantly affects lung and liver. Individuals with severe AATD mutations, such as the PiZZ genotype, face increased risks of liver cirrhosis and lung emphysema. Over the past 10 years, our group has collated a worldwide unique and well characterised human tissue samples. In your thesis, you will take advantage of these patient-derived cells to study how neutrophils contribute to AATD. The research will explore the impact of inflammation, immune cell activation, and their interactions with liver function. Advanced omics analyses and biochemical assays will be employed.