PhD student in Cancer Research

at  Luxembourg Institute of Health

BACKGROUND

Chronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly uncurable disease. This cancer is caracterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on complex interactions between tumor cells and their microenvironment. We have previously demonstrated that small extracellular vesicles (sEV) are key players in CLL by promoting the formation of cancer-associated fibroblasts and PD-L1+ monocytes. Importantly we showed that sEVs are indispensable for leukemogenesis in vivo by impairing T-cell mediated anti-tumor immunity.

KEY SKILLS, EXPERIENCE AND QUALIFICATIONS

• Master’s degree in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage, but is not mandatory.
• Experience in cell culture, PCR, Western-Blot, imaging and flow-cytometry techniques.
• Mouse experimentation practice and FELASA diploma (or equivalent) would be considered as an asset.
• Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, sense of priority and ability to work with others.
• Fluency in English is mandatory.
  More information about the group can be found here : https://tsi.lih.lu
  The applicants should submit a letter detailing their motivation and a curriculum vitaevia our website with the ref. : MC/PHD0724/TSI/EMJP. Applications will be reviewed shortly after receipt.

Please refer the Job description for details