Post-doctoral fellow in organic synthesis & chemical biology

at  KU Leuven

Post-doctoral fellow in organic synthesis & chemical biology
(ref. BAP-2024-557)
Laatst aangepast: 01/08/24
The Laboratory of Chemical Biology at the KU Leuven works on the development of chemical probes for covalent labeling of proteins as well as methods to study membrane-embedded enzymes. We utilize an interdisciplinary approach with techniques of organic chemistry, biochemistry, cell biology and proteomics to unravel functions of disease-relevant enzymes.
Project
The project entails a multi-institute and multidisciplinary collaboration of the Laboratory of Chemical Biology at KU Leuven with the University of Vienna, the University of Wollongong and the Center of Molecular Neurobiology at the University of Hamburg. The aim is to reveal diversity in synapses and their functional implications in neuronal disease. To this end, we will take approaches involving molecular biology, chemical probes, lipid nanodiscs, MS-based lipidomics, MALDI imaging and superresolution imaging to reveal differences in lipid composition at the post-synaptic interface. At each site, a post-doctoral fellow will work on an own project but will interact with and/or physically visit the other partners. At KU Leuven, the focus lies on development of photoaffinity labels for receptors of neurotransmitters as well as the development of laser-cleavable tags detectable by MALDI imaging.
Website van de eenheid

Responsibilities

• You will be responsible for synthesis of MALDI-tags and chemical probes for neuronal receptors
• You will be responsible for the isolation of lipid nanodiscs from membranes and isolated synapses
• You will interact with other post-docs from the consortium
• You will report results and prepare manuscripts for publication

Profile

• PhD degree in chemistry or chemical biology
• Experience with solution phase synthesis & purification methods
• A strong interest in biochemistry
• Experience with photoaffinity labeling and biochemistry techniques is a plus, but no necessity
• Excellent English communication skills
• Ambitious, motivated, creative and practically skillful

Offer
We offer a post-doctoral position for 1 year in a stimulating, interdisciplinary environment and scientific development opportunities in an international and dynamic team. You will have access to state-of-the-art research facilities. You will be supervised by well-trained scientists and receive thorough training in conducting research, presentations and writing.
Interested?
For more information please contact Prof. dr. Steven Verhelst, tel.: +32 16 37 45 17, mail: steven.verhelst@kuleuven.be.
You can apply for this job no later than August 31, 2024 via the online application tool
KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.
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Tewerkstellingspercentage: Voltijds
locationcity
Locatie : Leuven
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Solliciteren tot en met:

• You will be responsible for synthesis of MALDI-tags and chemical probes for neuronal receptors
• You will be responsible for the isolation of lipid nanodiscs from membranes and isolated synapses
• You will interact with other post-docs from the consortium
• You will report results and prepare manuscripts for publicatio