Postdoctoral researcher to develop antisense therapies for familial Alzheim

at  VIB

DESCRIPTION

The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper in collaboration with the Laboratory for Therapeutic and Diagnostic Antibodies headed by Prof. Maarten Dewilde, is looking for a motivated postdoctoral scientist to join our multidisciplinary project on gene therapy for Alzheimer’s Disease.
This work is focused on the specific targeting of clinical mutations that cause dominant inherited Alzheimer’s disease using a unique antisense strategy (ASO). We will couple those ASO to our proprietary blood-brain shuttles to improve brain exposure, improve administration via intravenous instead of intrathecal routes, and decrease toxicity associated with ASO treatment.
The candidate will be involved in both the generation and the testing of the ASO constructs and will follow the clinical candidates on their journey from preclinical to clinical application.

Additional information may be found in the following selected references:

• De Strooper, B. & Karran, E. New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of gamma-secretases. EMBO J 43, 887-903 (2024).
• Rue, L. et al. Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics 15 (2023).

Please refer the Job description for details