Postdoctoral Scientist - Neurobiology - Dr Michel Goedert

at  Medical Research Council

Open Date
21/10/2024, 08:00
Close Date
18/11/2024, 23:55
Research Institute
MRC Laboratory of Molecular Biology
Research Institute / Unit Information
The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.
There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.
The LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org
Band

MRC - 4

Location
Cambridge
Salary
£39,375 per annum
Contract Type
Fixed Term
Job Type
Science
Full Time / Part Time
Full Time
Contract Length
3 years
Job Description

ACADEMIC QUALIFICATIONS:

These should include a PhD in a relevant subject or due to complete PhD within 6 months.

TECHNICAL SKILLS AND EXPERTISE:

Essential:
Experience in cryo-EM structure determination and analysis, as well as in molecular biological techniques.
Desirable:
Previous work on amyloid filaments.

OTHER RELEVANT EVIDENCE OF:

• Commitment.
• Originality.
• Ability to communicate.
• Working with others.
  Further Information

You must at all times carry out your responsibilities with due regard to the UKRI:

• Code of Conduct
• Equality, Diversity and Inclusion policy
• Health and Safety policy
• Data Protection policy

Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager.
The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.
The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
The MRC is a unique working environment where scientific researchers and professional support staff can actively partake in world class innovation and collaboration opportunities and their skills and knowledge through accessing a wide catalogue of training & development, including professional registration with the Science Council.
In addition, MRC (part of UKRI) provides its community of employees access to a whole host of useful benefits, including a defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits
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UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment

OVERALL PURPOSE:

To work in the group of Dr Michel Goedert at the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to investigate mechanisms that cause the formation of amyloid filaments with structures like those from human brains.
Assembly of the proteins tau, alpha-synuclein and beta-amyloid into abnormal amyloid filaments is central to the development of most cases of human neurodegenerative disease. Since 2017, we have been using electron cryo-microscopy (cryo-EM) to determine the structures of these filaments from human brains. We have shown that specific filament folds define distinct diseases, with differences in filament structures being between some diseases, not between individuals with a given disease. To understand mechanisms of disease, one must be able to form filaments in experimental settings that have the same structures as those from human brains. This post is for making filaments of amyloid-beta from expressed proteins that have the same cryo-EM structures as parenchymal and blood vessel amyloid-beta filaments from the brains of individuals with Alzheimer’s disease. If successful, the postholder will also be involved in the production of conformation-dependent nanobodies that distinguish between filamentous parenchymal and blood vessel deposits of amyloid-beta.

MAIN DUTIES:

• To undertake research aimed at understanding mechanisms of neurodegeneration.
• To identify, develop and apply a broad range of techniques to pursue the research objectives.
• To present scientific work at seminars within the laboratory and at external meetings.
• To contribute to laboratory-wide discussions on developments within the field.
• To draft scientific papers, and contribute to the overall preparation of research for publication.
• To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
• To assist in the training of PhD students and other members of the LMB.

KEY RESPONSIBILITIES:

Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan.
To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.
To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.
To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.
To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
To enhance your research and generic skills through a tailored development programme.

You must at all times carry out your responsibilities with due regard to the UKRI:

• Code of Conduct
• Equality, Diversity and Inclusion policy
• Health and Safety policy
• Data Protection polic