Principal Bioinformatician

at  The University of Manchester

PRINCIPAL BIOINFORMATICIAN

• Salary within the range of £38,000 - £45,000 per annum (depending upon experience)
• Job Ref: MI/24/45
• Duration of post: Fixed term until 31st August 2027

The optimised classifier will then be validated in a large cohort of cfDNA samples from patients with known cancer types. This is an exciting opportunity to develop and apply computational methods to high-throughput data in a translational research project with a clear line of sight to clinical application.

• (1)Conway, Pearce, Clipson et al. Nature Communications (2024); (2)Chemi, Pearce et al. Nature Cancer (2022)

We are pleased to be able to offer the opportunity for a Principal Bioinformatician to join the NBC, to work on the optimisation and validation of our TOO classifier1. You will work alongside our multidisciplinary team of clinicians, molecular biologists, and computational scientists on a Cancer Research UK funded project to develop CUPiD towards a clinically validated approach.

The main area of focus will be the development and application of statistical/machine learning approaches to enhance classifier performance, for example through:

• Refinement of data augmentation strategies for generating training data sets;
• Multi-omic data integration, combining genomic and fragmentomic features alongside methylation profiles;
• Optimisation of classifier hyperparameters;
• Improved statistical models for normalisation of our genome-wide methylation sequencing data and for detection of differentially methylated regions.

The optimised classifier will then be validated in a large cohort of cfDNA samples from patients with known cancer types. This is an exciting opportunity to develop and apply computational methods to high-throughput data in a translational research project with a clear line of sight to clinical application.

• (1)Conway, Pearce, Clipson et al. Nature Communications (2024); (2)Chemi, Pearce et al. Nature Cancer (2022).