Principal Bioinformatics Scientist II

at  Roche

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.
The Position
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come.
Creating a world where we all have more time with the people we love. That’s what makes us Roche.
Roche Sequencing Solutions (RSS), a business within Roche Diagnostics, focused on developing an innovative Next-Generation Sequencing (NGS) platform along with a portfolio of reagents, assays and informatics solutions for multiple disease areas. We are looking for a Principal Bioinformatics Scientist in the NGS Algorithms and Applications team to support the algorithm development efforts.
In this role as a Principal Bioinformatics Scientist II , you will collaborate closely with assay scientists, software engineers and other bioinformatics scientists and apply your strong knowledge in next generation sequencing technologies.
This will include illumine SBS (sequencing by synthesis), nanopore, etc. to design and develop algorithms for read processing, alignment, and variant (SNV, SV, insertions/deletions, CNV, TMB, MSI) callers etc. This will be used in our products that will affect patient care.

The Opportunity:

• Lead algorithm development effort for NGS applications including conceptualization, method development and implementation of production level algorithms in an Agile environment.
• Follow software development process and deliver and maintain documentation that explains why and how as well as the final design for scientific, marketing, and regulatory uses
• Present internally or externally (peer-reviewed publications or conference proceedings) and communicate updates across multiple functions in the organization. Transfer algorithm to production teams and provide scientific support for updates and maintenance
• Support bioinformatics pipeline to continue development for existing products.

Who You Are:

• You have a PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, Mathematics or other quantitative field combined with 7+ years of industry/post-doc experience of designing novel algorithms for NGS data analysis for example read processing, variant calling (SNV, insertions/deletions, CNV, SV, TMB, MSI etc.), variant annotation and analyzing large scale complex genomic datasets.
• You have 2+ years of experience in developing novel algorithms, complexity analysis, as well as demonstrated skills in statistical and mathematical modeling
• You have experience implementing high-quality and efficient product level code.
• You have 2+ years of experience of sequencing (long and/or short read), cancer molecular biology, bioinformatics tools, statistical methods.
• You are proficient with programming languages (C++) in a distributed Linux environment
• You have hands-on experience using a workflow management system such as Nextflow or Snakemake, using Docker and cloud computation resource and storage

Please refer the Job description for details