Process Development QC scientist

at  Kings College London

Job id: 098725. Salary: £38,232 - £42,999 per annum, including London Weighting Allowance.
Posted: 01 November 2024. Closing date: 24 November 2024.
Business unit: Research Platforms. Department: Gene Therapy Vector Facility.
Contact details: Gaurav Bhavsar. gaurav.bhavsar@kcl.ac.uk
Location: Guy’s Campus. Category: Professional & Support Services.
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About us
The King’s College London Gene Therapy Vector Facility (GTVF) provides comprehensive GMP-grade viral vector manufacturing services. This includes Lentiviral Vector (LV), Retroviral Vector (RV) and Adeno-Associated Viral Vector (AAV) production for early-phase clinical trials, alongside substantial programmes in process innovation, knowledge transfer and training to address critical skills shortages.
In partnership with the Network of Innovation Hubs, our vision is to ensure that the UK capitalises on its outstanding academic medical research to deliver novel gene therapies to patients, providing transformative treatments for currently intractable conditions, and generating a vibrant economic landscape.
The GTVF is run by a large, industry-leading team of >50 people who have extensive experience in delivering end-to-end viral vector manufacture for both academic and commercial clients, with a focus on early-stage clinical trials.
About the role
The Process Development QC Scientist for the Gene Therapy Vector Facility (GTVF) is responsible for the testing and analysis of the QC samples generated from the Viral Vectors manufacturing process in process development lab.
The post holder will work closely with colleagues in Upstream and Downstream team members in process development department. The post holder will also work very closely with colleagues in other department including MSAT, QC and QA teams and support as and when required.
The post holder is responsible for testing of the analytical samples and evaluating the results in timely manner and writing reports. The successful candidate will be working under the direction of Head of Process Development / Technical Director.
The post holder will be responsible for the technical evaluation of QC sample strategy and proposing targeted lab work to optimise the analytical testing processes.
This is a full time (35 hours per week) post and will be offered an indefinite contract.
About you
To be successful in this role, we are looking for candidates to have the following skills and experience:
Essential criteria
1. B.Sc/M.Sc/Ph.D degree in a Biochemical Engineering or Life science discipline.
2. Experience of working in commercial companies within process development at Pharma/Biotech/Contract Manufacturing organisation (CMO) sectors.
3. Experience on Viral Vector quantification and quality assessments using qPCR/dPCR, ELISA, Western blot, Cell based Potency assay, infectious genome assays and flowcytometry.
4. Extensive hands-on skills and experience with molecular biology, cell culture techniques, and cell-based assays
5. Previous experience of working with AAV or LV for analytical tests
6. Experience in analytical methods development and transfer to GMP QC would be beneficial.
7. Experience of working with in compliance with regulatory requirements and quality standards including those of ICH, ISO, GMP and Good Laboratory Practice.
8. Excellent verbal and written communication skills and comfortable working independently and building professional networks.
9. High level of work organization, self-motivation, drive for performance and improvement and flexibility in approach and attitude.
Desirable criteria
1. Experience of successfully development of analytical methods for Viral Vectors like Adeno associated, Lenti virus and Retro Viruses.
2. Experience in tech transfer of analytical methods to GMP QC team
3. Understanding of and familiarity with regulatory guidance governing viral vector and biopharmaceutical development
Downloading a copy of our Job Description
Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “

Please refer the Job description for details