Purification Scientist

at  PerkinElmer

QUALIFICATIONS/PERSONAL QUALITIES:

• Bachelor’s degree with 3+ years of experience or Master’s degree with 2+ years of experience in chemistry, analytical chemistry or a similar scientific discipline.
• Demonstrated working familiarity with different analytical and preparative techniques.
• Strong desire to learn with multifunctional learning agility.
• Self-motivated.
• Outstanding verbal and written communication.
• Basic preparative instrumentation knowledge including simple maintenance and repair.
• Ability to multitask across purification and analysis.
• Ability to manage the workflow within the group.
• Experience with analytical method development and preparative chromatography in small molecule pharmaceuticals.
• Ability to analyse chromatographic data and make decisions for follow up experiments
• Awareness of Waters analytical and preparative chromatography systems.

• Deliver a flow process, involving varied instrumentation platforms, to enable the isolation of compounds of interest from crude mixtures.
• Utilise relevant analytical instrumentation for separations method development; primarily analytical UPLC-MS.
• Operate mass-directed automated purification (MDAP) HPLC platforms to purify complex, crude sample mixtures.
• Identify desired chromatographic fractions and consolidate for isolation using liquid handling robots.
• Removal of chromatographic purification solvents by lyophilisation and generation of post-purification analysis samples for multiple techniques, such as UPLC-MS and NMR.
• Use liquid handling technology and other appropriate instrumentation (including nitrogen dry-down units and lyophilisation units) to dispense purified compounds for ongoing screening.
• Oversee the collection of appropriate analytical data to characterise and register final drug candidate molecules prior to organising submission for screening.
• Document purification conditions and method development used to isolate compounds and provide this information to the originating chemist.
• Maintain instrumentation as appropriate and escalate any identified instrumentation or hardware issues that cannot be resolved locally to next level support, as determined by GSK.
• Support CAPS scientists with evaluations of new chromatographic systems and related processes as appropriate.
• Operate and maintain laboratory equipment in accordance with appropriate internal maintenance SOPs and work instructions.
• Collect service metrics where applicable.
• Follow all safety protocols and operating requirements as defined by local management and GSK policy.
• Liaise with colleagues to determine the appropriate consumable provisions required to support ongoing CAPS progression.
• Perform routine lab maintenance & organisation.
• Support process improvement projects related to service deliverables as capacity allows and as approved by the PE team manager.