Research Assistant/Associate in Cell Biology (Fixed Term)

at  University of Cambridge

A postdoctoral Research Associate position in Cell Biology is available in the Cambridge Institute for Medical Research (CIMR) to work with Dr Nick Bright, Professor Paul Luzio and Professor David Owen on an MRC research project entitled “Organelle remodelling and function of endolysosomes, lysosomes and secretory lysosomes” The aim of this project is to study the mechanisms regulating lysosomal pH and specifically the assembly of V-ATPase on endolysosomes and disassembly on reforming lysosomes. The work follows on from a recent publication doi: 10.1091/mbc.E23-08-0322.
Applicants should have a good knowledge of intracellular membrane traffic and established skills in some or all of generating plasmid constructs and stably transfected/transduced mammalian cell lines, depleting proteins by knockdown or knockout, confocal fluorescence microscopy (including live cell microscopy and colocalisation analysis), electron microscopy, subcellular fractionation and biochemical assays. Experience of biochemical methods to study protein interactions, some knowledge of using alphafold and a proven ability to interact with structural biologists would be an advantage. Specialised training in confocal and electron microscopy will be available.
Applicants must have a PhD in cell biology, biochemistry or a related subject but applications will also be considered from candidates who have just submitted their thesis and are in the process of viva/formal confirmation.
The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic with a mission to determine the molecular mechanisms of disease in order to advance human health.
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Please refer the Job description for details