Research Assistant, Senior (Warren Center, Plumley Lab)

at  Vanderbilt University

The position calls for a motivated biological scientist to join the Molecular Pharmacology group within the WCNDD. The Pharmacology team is responsible for conducting high-throughput screening assay of small molecule modulators of GPCRs, ion channels, and kinases. This includes development of target protein cell lines and pharmacological assay to lead and support all molecular pharmacology activities. This position is a key contributor to support the Center’s goal of developing therapeutics, specifically for central nervous system disorders. Successful candidates will interface with members among all areas of the WCNDD, including those in molecular pharmacology, medicinal chemistry, drug metabolism and pharmacokinetics, and in vivo rodent pharmacology.

QUALIFICATIONS

• Bachelor’s degree with 4 plus years of relevant working experience or master’s degree (MS) with 2 years of relevant work experience.
• Degree in biology, biochemistry, or pharmacology is necessary.
• A minimum 4 years’ experience in mammalian cell culture is necessary.
• Hands-on experience of plasmid preparation, transfection, and Western Blotting.
• Excellent oral and written communication skills, excellent data analysis capabilities, and proficiency with curve fitting and graphing programs are essential.
• Good documentation practices with excellent organization and attention to detail
• Self-motivated team player with the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment.

We are all different, yet we all use our unique contributions to serve patients. The Molecular Pharmacology Research Assistant Senior we seek is a person with these qualifications.

• Perform in vitro pharmacological experiments independently or under moderate supervision.
• Conduct high-throughput cell-based screening assays
• Operate multi forms of liquid handling equipment, and automation units.
• Maintain mammalian cell lines used in the screening assays.
• Develop stable cell lines specific to new target proteins.
• Perform molecular biology experiments involving preparation and analysis of DNA/RNA and Protein samples.
• Train junior research associates in pharmacological assay, equipment operation/maintenance, and data analysis.
• Contribute to the effective operation of the lab by ordering supplies, maintaining equipment, and ensuring compliance with VEHS biological and chemical safety requirements.
• Write up pharmacological assay protocols applicable to assigned tasks.
• Analyze data to determine the efficacy and potency of the compounds using data analysis software.Maintains accurate databases and experimental notebooks of results

DUTIES AND RESPONSIBILITIES

We are all different, yet we all use our unique contributions to serve patients. The Molecular Pharmacology Research Assistant Senior we seek is a person with these qualifications.

• Perform in vitro pharmacological experiments independently or under moderate supervision.
• Conduct high-throughput cell-based screening assays
• Operate multi forms of liquid handling equipment, and automation units.
• Maintain mammalian cell lines used in the screening assays.
• Develop stable cell lines specific to new target proteins.
• Perform molecular biology experiments involving preparation and analysis of DNA/RNA and Protein samples.
• Train junior research associates in pharmacological assay, equipment operation/maintenance, and data analysis.
• Contribute to the effective operation of the lab by ordering supplies, maintaining equipment, and ensuring compliance with VEHS biological and chemical safety requirements.
• Write up pharmacological assay protocols applicable to assigned tasks.

• Analyze data to determine the efficacy and potency of the compounds using data analysis software.Maintains accurate databases and experimental notebooks of results.

At Vanderbilt University , our work - regardless of title or role - is in service to an important and noble mission in which every member of our community serves in advancing knowledge and transforming lives on a daily basis. Located in Nashville , Tennessee, on a 330+ acre campus and arboretum dating back to 1873, Vanderbilt is proud to have been named as one of “America’s Best Large Employers” as well as a top employer in Tennessee and the Nashville metropolitan area by Forbes for several years running. We welcome those who are interested in learning and growing professionally with an employer that strives to create, foster and sustain opportunities as an employer of choice through:

• Working and growing together as a community of communities… we are One Vanderbilt .
• Providing a work environment where every staff and faculty member can be their authentic and best self , while providing the resources and opportunities to learn and grow.
• Encouraging development, collaboration, and partnership both internally and externally while fostering the value that every member of the Vanderbilt community can lead and grow regardless of title or position