Research Assistant

at  Trinity College Dublin

Research Assistant
Thoracic Oncology Research Group, Department of Clinical Medicine, School of Medicine, Trinity College Dublin, the University of Dublin
Biomarker testing often requires invasive tissue-based procedures for assessment, often compromised by tumor heterogeneity and discomfort for patients, especially those with metastatic disease. Research by the HEA funded All-Ireland Cancer Liquid Biopsies Consortium (CLuB), NCI collaborators and others has identified valuable tumor-derived information present in blood, highlighting the potential of the liquid biopsy (LB) as a noninvasive alternative that complements tissue biopsies. The LB tumor circulome comprises circulating tumor cells (CTCs), tumor DNA (mutated/methylated), RNA, proteins and extracellular vesicles (EVs) implicated in various cancer processes. This project, funded by the All-Ireland NCI Cancer Consortium (AICC) research & innovation grant scheme will develop a new TransAtlantic research alliance combining the strengths of CLuB and NCI LB experts to evaluate ctDNA fragmentomic and methylation profiles, at multiple time-points, in a longitudinal cohort of 100 patients with resectable NSCLC. It will assess their individual predictive value and added value of co-analysis with CLuB’s CTC and EV data, using multimodal bioinformatics pipelines. It will prioritize dissemination of project results to patients and the public and develop a training programme for future leaders by supporting mobility of researchers and clinical fellows between Irish institutes (North and South) and Johns Hopkins University, US. Joining forces with international LB experts will drive innovation and enable implementation of novel LB assays in the clinic

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