Research Associate

at  Imperial College London

WHAT WE ARE LOOKING FOR

We are looking for an enthusiastic researcher who has just completed a PhD in a relevant area of neuroscience and has experience of working with human brain tissues. You will have:

• Experience with RNA and protein analysis techniques and immunostaining.
• Working knowledge of human neuroanatomy and neuropathology.
• Knowledge of neurodegenerative and neuroinflammatory disease mechanisms.
• Some experience with bioinformatics data analysis.
• A creative approach to problem solving.
• Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant.

AVAILABLE DOCUMENTS

Attached documents are available under links. Clicking a document link will initialize its download.

• Download: Research Associate Job Description.Pdf

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.
If you encounter any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help.

ABOUT THE ROLE

Our research aims to understand the cellular and molecular mechanisms underlying neurodegeneration and the consequent accumulation of disability in progressive Multiple Sclerosis (MS). The Research Associate in Neurodegeneration will be using then latest multi-omics technologies on human post-mortem brain tissues to analyse the molecular pathways that lead to neuroinflammatory and neurodegenerative pathology in MS. By analysing ligand receptor interactions at the single cell level in the MS brain, we ultimately aim to identify new drug targets to take forward for therapeutic development

WHAT YOU WOULD BE DOING

You will be optimising and using whole genome spatial transcriptomics to study gene expression at a single cell resolution level on a large cohort of post-mortem MS tissues that are being selected for the presence of more extensive neurodegenerative and inflammatory pathology. This will be followed by bioinformatics analysis of the data to identify genes and pathways of interest. You will then use multiplex immunofluorescence techniques to verify protein expression and in vitro experimental models to begin to understand gene function and relevance to MS pathogenetic mechanisms.