Research Associate

at  Imperial College London

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ABOUT THE ROLE

We are seeking a highly motivated Postdoctoral Research Associates to work in the Section of Molecular Microbiology, which is part of the Centre for Bacterial Resistance Biology at Imperial College London, UK. The position is funded through the Wellcome Trust and is fixed term for 12 months. The work will involve the investigation of essential genes in the bacterial pathogen Staphylococcus aureus.

WHAT YOU WOULD BE DOING

The research project will focus on the Gram-positive bacterial pathogen Staphylococcus aureus and the work will be conducted in the laboratory of Professor Angelika Gründling. You will focus on understanding cellular processes that are controlled by the essential signalling nucleotide c-di-AMP in S. aureus with the long-term goal to use this knowledge to develop new methods to prevent the growth, colonization and infection with this organism. c-di-AMP is a more recently discovered signalling nucleotide required for the growth of S. aureus under standard growth conditions and plays an important role in osmotic regulation and cell wall homeostasis. Recent work from the lab has shown that while c-di-AMP is essential for growth under aerobic growth conditions, it becomes dispensable under anaerobic conditions. The project will focus on investigating metabolic changes that occur when S. aureus growths aerobically versus anaerobically as well as provide a better understanding of essential genes under aerobic versus anaerobic growth conditions. The project will use amongst others the Tn-seq methodology and be follow up work on already generated Tn-seq data.