Research Expert Trellis

at  KU Leuven

Research Expert Trellis
(ref. OZK-2024-45)
Laatst aangepast: 16/09/24
The Trellis team, embedded in the Departments of ‘Cellular and Molecular Medicine’ and ‘Microbiology, Immunology and Transplantation’ at KU Leuven, is looking for a motivated and skilled research expert to join its Gene Therapy Discovery Science team and to conduct research on several aspects of adeno-associated virus (AAV)-based gene therapy. The senior researcher will act as an expert in AAV viral vector production (upstream), analytical development and capsid engineering.

• Upstream development of a scalable and robust manufacturing platform for AAV vectors.
• Applying bioprocess engineering strategies to optimize AAV production in suspension cells. Knowledge of DOE design and power analysis is a plus.
• Independently planning and executing studies on the development of the manufacturing process and analytical testing of AAV viral vectors.
• Exploring, stimulating and implementing innovative technologies and processes in the field.
• Designing, executing and documenting assays to characterize and quantify viral vectors, including managing collaborations with partners and external service providers.
• Contributing to novel AAV capsid and vector engineering efforts to tackle current challenges in the field.
• Managing a team of 2-4 technicians, and providing guidance to M.Sc. and Ph.D. students.
• Applying expertise in manufacturing and analytical testing to review workplans, activities and reports and maintain timelines and budgets.
• Establishing and nurturing collaborations with national and international academic and industrial partners on gene therapy product development and production.
• Serving as a subject matter expert in AAV viral vector production, providing technical guidance and insights to the team and stakeholders.
• Actively participating in internal and external research meetings to contribute insights and foster collaboration