Research Fellow

at  University College London

ABOUT US

The UCL Cancer Institute (https://www.ucl.ac.uk/cancer/) is the hub for cancer research at University College London, one of the World’s leading universities. The Institute draws together over 400 talented scientists who are working together to translate research discoveries into developing kinder, more effective therapies for cancer patients.
The aim of this post is to develop the first immunocompetent mouse model of human T-ALL by: 1) generating synthetic T-ALL with defined genetic lesions in human haematopoietic stem cells (HSCs), 2) engrafting HSCs from the same donor into immunodeficient mice for humanised haematopoiesis, 3) introducing the synthetic T-ALL.

ABOUT THE ROLE

This role will be based in the Maciocia laboratory at UCL Cancer Institute, with additional supervision from Professor Marc Mansour. The postholder will further develop a model of synthetic human T-ALL and for the first time apply this in an immunocompetent setting. The post will involve molecular cloning, lentiviral production, HSC isolation and manipulation, complex analysis using flow cytometry, RNA-seq and other tools. There will a large component of murine work involved in establishing, validating and testing the model. There is a substantial focus on development and testing of new immunotherapies for T-ALL, with a focus on CAR-T.
The post is funded for 24 months in the first instance.
Your application should include a CV and a Cover Letter: In the Cover Letter please evidence the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the ‘Why you have applied for this role’ field in the application form, which is limited in the number of characters it will allow.)

As well as the exciting opportunities this role presents we also offer some great benefits some of which are below:

• 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days)
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insuranc