Research Fellow

at  University College London

ABOUT US

The UCL Huntington’s Disease Centre, based in the Department of Neurodegenerative Disease, is uniquely placed world-wide to translate mechanistic insights to ‘first in human’ studies. It combines sophisticated cell-based systems with rigorously standardised preclinical target validation to prime mechanistically-driven drug development initiatives. The Centre integrates clinical and laboratory work with small proof-of-concept first in human studies in patients in the Leonard Wolfson Experimental Neurology Centre (LWENC) prior to initiating larger phase 2 and 3 clinical trials including novel huntingtin-lowering trials.

ABOUT THE ROLE

We are recruiting a Research Fellow to contribute to a project examining the role of the HD genetic modifier PMS1 within Professor Sarah Tabrizi’s research group at the Huntington’s Disease Centre.
You will help determine whether PMS1 expression or specific functions of the protein can modify somatic expansion of the HTT CAG repeat region. You will also assess whether therapeutic targeting of PMS1 expression via small molecule-based lowering can modify this phenotype.
This is an internal recruitment advert, available to eligible UCL workers only. The post is offered part-time at 5.475 hours per week (0.15 Full Time Equivalent).
The role is available immediately and is funded by a research grant from Rgenta Therapeutics until 31 August 2025.
If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team (ion.hradmin@ucl.ac.uk).
Informal enquiries regarding the role can be addressed to Professor Sarah Tabrizi (s.tabrizi@ucl.ac.uk).
A full job description and person specification for this role can be accessed below.

As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• On-site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insuranc