Research Scientist, Medicinal Chemistry

at  Bicycle Therapeutics

Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination
• We are One Team. We only succeed when we work together.

Job Description
We have a new opportunity for a Research Scientist who will join a dynamic and fast-moving team and will be primarily responsible for the design and synthesis of novel Bicycles and conjugates with a goal of developing lead candidates. In this role you will be required to manage external resources to deliver on synthetic and analytical tasks and will also work collaboratively with the scientific team in a project team environment to progress Bicycle’s oncology pipeline.
You will have demonstrated a good level of proficiency in modern synthetic organic / medicinal chemistry as applied to drug discovery and lead optimization of small molecules and peptides and will have experience in the application of structure based design, the use of non-natural amino acids, linkers and conjugation chemistries. You will work as part of the Medicinal Chemistry team and will contribute to the chemical optimisation of Bicycle monomers and the design and synthesis of Bicycle oncology agents via external CRO partners. For project centric activities, data and progress review, the role will involve close interaction with the Platform, Biology, DMPK and in vivo Pharmacology teams.

KEY RESPONSIBILITIES:

• Supporting chemistry activities within a project team, including the design of bioactive Bicycle® peptides to a set Target Product Profile
• Serve on internal project teams, communicate with project team and colleagues effectively and work well with others to meet experimental and organizational goals.
• Present the results of research activities effectively in oral or written form to line manager, project team members and management level meetings.
• Coordinate chemistry at external contract research organizations (CROs) including maintaining a good relationship, development of chemistry plans, project tracking, data and compound management, evaluation of results and analytical data including NMR, LCMS, HPLC, UV-VIS and troubleshooting synthetic issues.
• Prepare reports and contribute to drafting patent filings and journal manuscripts
• Supporting the development of new innovations which expand the company platform
  Qualifications

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination
• We are One Team. We only succeed when we work together