Research technician

at  Erasmus MC

RESEARCH TECHNICIAN

Molecular functions and therapeutic potentials of human BAF complexes in acute myeloid leukemia.
Closing date 13-11-2024
42.20.24.TDdH

JOB DESCRIPTION

Acute myeloid leukemia (AML) is a type of hematological malignancies that is driven by many different transcription factors. Although the transcription factors are the key oncogenic drivers in AML, these proteins are difficult to be pharmacologically targeted. However, transcription factors always require many co-activators to control oncogenic transcriptional program. These co-activators are often druggable. Among these transcriptional co-activators, human BRG1/BRM associated factor (BAF) complexes play a critical role in many types of cancer including AML, and may also be the important therapeutic targets.
We are looking for a highly motivated research technician who is interested in studying molecular aspects of hematological malignancies. We will combine state-of-the-art gene editing, (epi)genomics, and computational methods to study the molecular functions of the BAF complexes in AML. Furthermore, we will test our anti-BAF therapies in 2D and 3D (primary) culture models. The ultimate goal of our research is to develop novel anti-AML therapeutics for AML treatment.
The initial employment will be one year, with a possible extension for 3 years after a positive evaluation.

QUALIFICATIONS AND SKILLS

Requirements:

• You have a BSc/MSc in either (molecular) biology, genetics, or (bio)chemistry.
• Solid experience with molecular biology techniques, mammalian cell culture, and FACS analysis is a requirement;
• You are familiar with gene editing techniques such as CRISPR-CAS9.
• You are team-oriented, highly motivated, self-driven, and proficient in written and spoken English.

Desirable skills:

• You have experience in the relevant fields such as hematology or immunology.
• You are fimilar with epigenetic techniques such as ChIP-seq and ATAC-seq.
• You are familiar with human iPSC and/or organoids culture.

Before you apply please check our conditions for employment.

Please refer the Job description for details