Scientist

at  Apellis Pharmaceuticals

Waltham, Massachusetts, USA -

Start DateExpiry DateSalaryPosted OnExperienceSkillsTelecommuteSponsor Visa
Immediate22 Jan, 2025Not Specified22 Oct, 20243 year(s) or aboveDna,Cell Culture,Excel,Molecular Biology,Biochemistry,Powerpoint,Cell Biology,Graphpad Prism,PharmacologyNoNo
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Description:

POSITION SUMMARY:

We are seeking a talented and highly motivated individual to join the research team at Apellis Innovation Laboratory in Watertown, MA. The individual will be part of the Non-Clinical Development bioanalytical group, contributing to the discovery of novel treatments for ocular and neurologic diseases by targeting the complement cascade. The primary responsibility of this position will be to conduct sample preparation, analysis, and method testing for in vivo and in vitro pharmacology studies on various platforms such as protein assays (using platforms such as Simoa/Quanterix, Meso Scale Discovery (MSD), ELISA, Jess/western etc.) and mRNA assays (utilizing platforms such as qPCR, ddPCR, etc.) across a wide range of matrices/species.

EDUCATION, REGISTRATION & CERTIFICATION:

  • MS or BS in biochemistry, pharmacology, or life-sciences related program.

EXPERIENCE:

  • MS plus 3 years or BS plus 5 years of direct bench research experience, preferably in biopharmaceutical industry setting.
  • Solid hands-on experience in immunoassay analysis and method testing is required and experience using MSD, and/or Quanterix platforms is highly preferred.
  • Knowledge of and ability to troubleshoot assay matrix effects, specificity, and limits of quantitation/detection is required.
  • Other cell biology, molecular biology and biochemistry techniques (such as cell culture, DNA and RNA extraction, qPCR, Western blot/WES/JESS, and ELISA and other ligand binding assays) are a plus.
  • Understanding of bioanalytical best practices and FDA guidelines a plus.

SKILLS, KNOWLEDGE & ABILITIES:

  • Highly motivated team player, willing to contribute where needed in a flexible and fast-paced environment.
  • Strong organizational skills and attention to detail.
  • Ability to effectively communicate ideas and data interpretations.
  • Disciplined documentation of experiments using electronic lab notebook.
  • Experience in using common research software applications (such as GraphPad Prism, Excel, PowerPoint).

TRAVEL REQUIREMENTS:

  • Up to 15% travel expected.

Responsibilities:

KEY RESPONSIBILITIES INCLUDE:

  • Conduct quality sample preparation and analysis on various platforms such as Simoa/Quanterix, Meso Scale Discovery (MSD), ELISA, Jess/western, qPCR and ddPCR to evaluate in vitro and in vivo samples across a variety of biological matrices/species.
  • Develop and implement biomarkers assays relevant for neurologic and ocular diseases and therapeutic targets.
  • Effectively communicate experimental results to study directors and management, presenting data at project team meeting, as needed.
  • Use critical thinking skills to analyze experimental data and comply with proper documentation practices via electronic laboratory notebook.
  • Contribute to experimental designs and assay development for internal and externalized projects.
  • Apply basic scientific principles to perform literature searches and extract relevant information from published protocols.
  • Participate in shared lab duties (such as reagent preparation, lab inspection, instrument maintenance, etc.) and lab meetings.

OTHER DUTIES:

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.


REQUIREMENT SUMMARY

Min:3.0Max:5.0 year(s)

Pharmaceuticals

Pharma / Biotech / Healthcare / Medical / R&D

Clinical Pharmacy

BSc

Proficient

1

Waltham, MA, USA