Scientist - Biochemistry & Pharmacology

at  Amgen

HOW MIGHT YOU DEFY IMAGINATION?

You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.
Scientist - Biochemistry & Pharmacology

BASIC QUALIFICATIONS:

Doctorate & relevant scientific experience
OR
Master’s degree & 2 years of scientific experience

PREFERRED QUALIFICATIONS:

• PhD in Biochemistry, Pharmacology, Cell Biology, Molecular Biology or a related field, with relevant postdoctoral experience preferred
• Expertise in quantitative pharmacology, enzymology, and ligand binding kinetics.
• Small molecule drug discovery experience in novel modalities including but not limited to reversible inhibitors, covalent inhibitors, or degraders.
• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc.
• Demonstrated ability to develop and implement cellular assays for target validation, hit identification, and lead optimization, such as MesoScale Discovery, HiBIT, NanoBRET, and cell reporter assays
• Highly skilled in the development & implementation of robust, automated, 384 or 1536-well plate-based assays using a wide range of detection methods (e.g., spectrophotometry, radiometry, luminescence, fluorescence)
• Experience with microplate readers and automated liquid handling systems (e.g., PerkinElmer Envision, Labcyte Echo, Agilent Bravo, etc.)
• Experience with data analysis and visualization software platforms (e.g., Genedata Screener, Tibco Spotfire, GraphPad Prism, etc.)
• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment

Let’s do this. Let’s change the world. Amgen is seeking a talented and motivated individual with expertise in biochemical & cell-based assay development in support of Amgen’s small molecule drug discovery pipeline. In this vital role you will be responsible for designing, developing, and optimizing assays to identify and validate potential drug candidates, including reversible inhibitors, covalent inhibitors, and degraders. The successful candidate should possess strong technical expertise & laboratory skills, have excellent written and oral communication skills, work productively in a collaborative cross-functional team environment, and keep current with field of expertise, including literature and technology development

• Develop and optimize biochemical assays to support HTS, hits validation, and lead optimization for novel therapeutic targets
• Develop and execute cell-based assays to assess the effects of small molecules on cellular pathways, receptor activity, and phenotypic outcomes
• Apply sophisticated bioassay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study
• Evaluate and implement new technologies to enhance screen capabilities and assay performance
• Stay current with scientific literature and industry trends related to assay technologies, novel drug modalities, and drug discovery
• Represent department in multi-disciplinary project teams to present research results and provide scientific and technical support
• Collaborate with internal cross-functional teams and external partners to enable project progression