Scientist – DNA-, RNA- Oligonucleotide Synthesis (x/f/m)

at  LGC Axolabs

Company Description
Axolabs specialises in a new class of drugs whose active ingredients are chemically derived from DNA or RNA. They are called oligonucleotide or nucleic acid therapeutics. We use our many years of expertise to help our clients make them a success. Some of these drugs have already been approved and are being used successfully against diseases that were previously untreatable in some cases. New drugs from this class are added every year.
We believe in Science for a Safer World and are currently seeking candidates who are up for the challenge of operating in a high-growth, purpose-driven organization. LGC Axolabs is located in Petaluma, US, Kulmbach and Berlin, Germany.
Job Description

JOIN OUR INNOVATIVE R&D TEAM IN OLIGONUCLEOTIDE CHEMISTRY!

Are you passionate about pushing the boundaries of oligonucleotide chemistry? We are looking for an experienced and motivated scientist to develop innovative synthetic approaches for complex oligonucleotide formats. If you thrive in a dynamic R&D environment and are eager to contribute to brand new projects, this role could be your next career step. Join LGC now and help us driving our mission of “Science for a Safer World”!

EDUCATION & PREFERRED QUALIFICATIONS

• Hands-on experience in oligonucleotide synthesis via automated solid-phase methodologies, complemented by a Ph.D. in Chemistry or Biochemistry, or equivalent experience
• Prior experience in ligation chemistry (enzymatic and/or chemical) is desired
• Proficient in conjugation and purification technologies, with expertise in HPLC, LC-MS, UV spectroscopy, and endotoxin measurement and control
• Strong oral and written communication skills in both English and German, with a keen ability to maintain detailed lab notebooks and reports
• A reliable, dedicated working style characterized by a focus on quality, dedication, and excellent communication skills

• Develop innovative synthetic and downstream processing routes for complex oligonucleotide formats, including conjugates with fatty acids, peptides, and antibodies
• Collaborate with the team to design and execute experiments that optimize lead oligonucleotide drug candidates, focusing on potency, selectivity, stability, and pharmacokinetic properties
• Take on responsibility for customer order projects after a thorough training period
• Support the Department Head in project planning, client communication, and report writing
• Analyze experimental data, interpret results, and present findings internally, to customers, or at international conferences. Contribute to technical reports and manuscripts for publication in peer-reviewed journals
• Guide and coach junior staff members in the oligonucleotide synthesis laboratory
  Qualifications