Scientist - High Throughput Screening

at  AstraZeneca

Cambridge CB2 0AA, England, United Kingdom -

Start DateExpiry DateSalaryPosted OnExperienceSkillsTelecommuteSponsor Visa
Immediate24 Apr, 2025GBP 38700 Annual24 Jan, 2025N/AGood communication skillsNoNo
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Description:

Title: Scientist High Throughput Screening
Location: Central Cambridge
Salary: Competitive
We are looking for an enthusiastic scientist to join our collaborative High Throughput Screening team, the only department within our world-leading pharmaceutical business which focuses unequivocally on hit identification of small molecules- giving our scientists unrivalled exposure to the drug discovery process in a culture that fosters true collaboration and open innovation.

WHO WE ARE

Within Discovery Sciences, the High Throughput Screening (HTS) group’s core purpose is to deliver small molecules that are active against a disease target of interest. These will be provided to project teams to initiate medicinal chemistry campaigns as a starting point for developing human therapeutics.
This is achieved using advanced robotics to rapidly test up to ~2M compounds through cell, biochemical or biophysical assays. Bespoke triage cascades need to be designed and implemented to build confidence in the quality of the hits.

ACCOUNTABILITIES:

Working closely with other HTS members and teams associated with the project, the role will take responsibility for delivering these screens in line with departmental and project needs. These projects will be prosecuted on behalf of all therapy areas within AstraZeneca including CVRM, Oncology and R&I or, in partnership with external collaborators.

  • Deliver HTS discovery projects in the laboratory as part of a team. Progress projects into and through the HTS portfolio taking responsibility for its successful delivery within agreed timelines
  • Collaborating with relevant teams (cellular and protein reagents, assay development etc) to coordinate that the delivery of their activities occurs in line with HTS and project needs
  • Representing HTS at the project team level communicating progress and issues effectively with the wider team members e.g. project lead, therapy area representatives, medicinal and computational chemists etc.
  • Transferring assays into HTS from the assay development groups and optimising the assays to function at scale. Performing comprehensive assay validation, delivering screening of up to ~2M small molecule compounds and confirming actives in concentration response format through all relevant cascade assays
  • Contributing to the troubleshooting of technical issues with assays and technologies via planning, execution and analysis of appropriate experimentation
  • Working closely with HTS colleagues, including the automation team and engineers, to support delivery of the broader portfolio of projects within HTS
  • In conjunction with the automation team, utilising the large automated robotic platforms to optimise and deliver screening activities
  • Analyse large datasets using appropriate statistical methods to ensure high quality data.

Responsibilities:

INTRODUCTION TO THE ROLE:

In a lab-based capacity, you’ll be tasked with delivering excellence in data generation for drug targets using cellular and biochemical assays using ana state-of-art robotic systems. . This incorporates aiding design of a project’s hit identification strategy and triage cascade, close cooperation with key groups in assay development and reagent supply and prosecution of the screening campaign. You’ll be responsible for guiding which assay technologies to apply for screening and supporting assay development colleagues to confirm they’re fit for purpose. You’ll further optimise the assays to ensure they work at large scale before profiling AstraZeneca’s compound collection to identify active compounds.

Working closely with other HTS members and teams associated with the project, the role will take responsibility for delivering these screens in line with departmental and project needs. These projects will be prosecuted on behalf of all therapy areas within AstraZeneca including CVRM, Oncology and R&I or, in partnership with external collaborators.

  • Deliver HTS discovery projects in the laboratory as part of a team. Progress projects into and through the HTS portfolio taking responsibility for its successful delivery within agreed timelines
  • Collaborating with relevant teams (cellular and protein reagents, assay development etc) to coordinate that the delivery of their activities occurs in line with HTS and project needs
  • Representing HTS at the project team level communicating progress and issues effectively with the wider team members e.g. project lead, therapy area representatives, medicinal and computational chemists etc.
  • Transferring assays into HTS from the assay development groups and optimising the assays to function at scale. Performing comprehensive assay validation, delivering screening of up to ~2M small molecule compounds and confirming actives in concentration response format through all relevant cascade assays
  • Contributing to the troubleshooting of technical issues with assays and technologies via planning, execution and analysis of appropriate experimentation
  • Working closely with HTS colleagues, including the automation team and engineers, to support delivery of the broader portfolio of projects within HTS
  • In conjunction with the automation team, utilising the large automated robotic platforms to optimise and deliver screening activities
  • Analyse large datasets using appropriate statistical methods to ensure high quality data


REQUIREMENT SUMMARY

Min:N/AMax:5.0 year(s)

Information Technology/IT

IT Software - Other

Software Engineering

BSc

Proficient

1

Cambridge CB2 0AA, United Kingdom