Senior Bioinformatician - In-silico Protein Design

at  TCypher Bio

SENIOR BIOINFORMATICIAN – IN-SILICO PROTEIN DESIGN

T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated Senior Bioinformatician with a strong background in protein engineering to advance our biologics platform as part of the Computational Biology team.

WHAT YOU WILL DO

This role will involve driving bioinformatics and ML-based efforts to engineer bispecific immune cell engagers towards our clinical programmes. The ideal candidate would have a strong background and interest in applying computational methods towards protein engineering, ideally including developability assessment. The role will involve exploratory bioinformatics, deploying ML-based approaches, and developing pipelines to expand on and enhance our analysis & data infrastructure.

KEY RESPONSIBILITIES

• Drive innovation in the application of computational techniques to protein engineering of clinical molecules
• Guide data generation to support development of new computational techniques and ML models
• Train and deploy ML approaches for improving protein engineering processes
• Develop and deploy tools and metrics for assessment of molecule developability
• Develop and integrate bioinformatics pipelines with our analysis & data infrastructure
• Regularly communicate findings and developments with the Research team and management
• Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects
• Maintain and implement good code, version control, and organisation of data