Senior (Principal) Associate - Oligonucleotide Synthesis & Purification

at  Roche

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.
The Position
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.
That’s what makes us Roche.
In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
This position is located in pRED Therapeutic Modalities, where we pave, in a diverse, ambitious and innovative environment, the path to bring drug candidates from early research into development.
The position holder will be member of the newly formed cross-functional RNAHub, where disease-biologists, nonclinical development experts, molecular biologists, molecule engineers, bioengineers and data scientists from various pRED functions join together to create and apply technologies that perturb RNA to discover drugs, biomarkers and targets.
The RNAHub takes a very data-centric approach, utilizing both artificial and human intelligence, that requires a high degree of data-literacy. In the RNAHub, we build a strong, collective and engaged community, where we employ, explore and evolve new ways of working in a research environment.

• Independently synthesize and purify complex oligonucleotides on different synthesis scales
• Develop and implement purification strategies for oligonucleotides, utilizing high throughput technologies (eg Hamilton, Tecan, Integra)
• Continuously improve synthesis and purification processes to enable successful scale up in the CMC early supply group
• General focus on increasing automation level and related workflows
• Perform analytical characterization of synthesized oligonucleotides using techniques such as HPLC and mass spectrometry
• Maintain detailed records of experimental procedures, results, and observations. Prepare technical reports and presentations for internal and external stakeholders.