At AstraZeneca’s Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world’s most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

POSITION SUMMARY

As a Senior Research Associate at Neogene, your primary responsibility is to conduct laboratory-based assays aiming to identify tumor biopsy-derived neo-antigen specific TCRs in functional genetic screens. Your responsibilities will include ensuring the accurate and reliable preparation and execution of assays, documenting the process and data meticulously, and maintaining the laboratory space and equipment relevant to your work. This position is located in Amsterdam, The Netherlands, and you will report to the Associate Director, Cellular Immunology.

EDUCATION AND EXPERIENCE

• Bachelor’s with 4 years or Master’s degree with 2 years’ experience in a relevant scientific field (e.g., Immunology, Oncology, Cell Biology or related discipline).
• 2 years of full-time laboratory experience using relevant technologies or in a similar role.
• Extensive hands-on experience with cellular biology methods, isolation and aseptic handling of primary cells and cell lines, in gene modification technologies (e.g. retroviral transductions), immunological assays, cell sorting and flow cytometry.
• Preference for candidates with experience in T cell immunology, genetic screening, or Cell therapy.
• Comfortable with electronic document management systems and authoring tools.
• You must be authorized to work in The Netherlands.
  

  LI-Onsite

• Work as part of the Cellular Immunology screening team to perform laboratory processes to select and characterize tumor biopsy-derived neo-antigen specific TCRs.
• Execute aseptic handling, AutoMACS-based cell sorting and genetic modification of immune cells and perform phenotypic and functional evaluation by flow cytometry.
• Work in compliance with standards set out by relevant accredited agencies.
• Collaborate in a team to discover and implement process improvements.
• Document results in electronic and paper-based laboratory journals and document management systems, following standards set by appropriate accredited agencies.
• Support the drafting and revising of batch records and SOPs to support process validation and for regulatory filings
• Write and revise protocols, SOPs, study plans and reports.